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A Personalized Cancer Vaccine that Induces Synergistic Innate and Adaptive Immune Responses
DC Field | Value | Language |
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dc.contributor.author | Kuen, Da-Sol | - |
dc.contributor.author | Hong, Jihye | - |
dc.contributor.author | Lee, Suyoung | - |
dc.contributor.author | Koh, Choong-Hyun | - |
dc.contributor.author | Kwak, Minkyeong | - |
dc.contributor.author | Kim, Byung-Seok | - |
dc.contributor.author | Jung, Mungyo | - |
dc.contributor.author | Kim, Yoon-Joo | - |
dc.contributor.author | Cho, Byung-Sik | - |
dc.contributor.author | Kim, Byung-Soo | - |
dc.contributor.author | Chung, Yeonseok | - |
dc.date.accessioned | 2024-06-13T02:10:42Z | - |
dc.date.available | 2024-06-13T02:10:42Z | - |
dc.date.created | 2023-08-08 | - |
dc.date.created | 2023-08-08 | - |
dc.date.issued | 2023-09 | - |
dc.identifier.citation | Advanced Materials, Vol.35 No.36 | - |
dc.identifier.issn | 0935-9648 | - |
dc.identifier.uri | https://hdl.handle.net/10371/204221 | - |
dc.description.abstract | To demonstrate potent efficacy, a cancer vaccine needs to activate both innate and adaptive immune cells. Personalized cancer vaccine strategies often require the identification of patient-specific neoantigens; however, the clonal and mutational heterogeneity of cancer cells presents inherent challenges. Here, extracellular nanovesicles derived from alpha-galactosylceramide-conjugated autologous acute myeloid leukemia (AML) cells (ECNV-& alpha;GC) are presented as a personalized therapeutic vaccine that activates both innate and adaptive immune responses, bypassing the need to identify patient-specific neoantigens. ECNV-& alpha;GC vaccination directly engages with and activates both invariant natural killer T (iNKT) cells and leukemia-specific CD8(+) T cells in mice with AML, thereby promoting long-term anti-leukemic immune memory. ECNV-& alpha;GC sufficiently serves as an antigen-presenting platform that can directly activate antigen-specific CD8(+) T cells even in the absence of dendritic cells, thereby demonstrating a multifaceted cellular mechanism of immune activation. Moreover, ECNV-& alpha;GC vaccination results in a significantly lower AML burden and higher percentage of leukemia-free survivors among cytarabine-treated hosts with AML. Human AML-derived ECNV-& alpha;GCs activate iNKT cells in both healthy individuals and patients with AML regardless of responsiveness to conventional therapies. Together, autologous AML-derived ECNV-& alpha;GCs may be a promising personalized therapeutic vaccine that efficiently establishes AML-specific long-term immunity without requiring the identification of neoantigens. | - |
dc.language | 영어 | - |
dc.publisher | WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim | - |
dc.title | A Personalized Cancer Vaccine that Induces Synergistic Innate and Adaptive Immune Responses | - |
dc.type | Article | - |
dc.identifier.doi | 10.1002/adma.202303080 | - |
dc.citation.journaltitle | Advanced Materials | - |
dc.identifier.wosid | 001034243200001 | - |
dc.identifier.scopusid | 2-s2.0-85165302296 | - |
dc.citation.number | 36 | - |
dc.citation.volume | 35 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Kim, Byung-Soo | - |
dc.contributor.affiliatedAuthor | Chung, Yeonseok | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | ACUTE MYELOID-LEUKEMIA | - |
dc.subject.keywordPlus | T-CELLS | - |
dc.subject.keywordPlus | DENDRITIC CELLS | - |
dc.subject.keywordPlus | B-CELLS | - |
dc.subject.keywordPlus | PHASE-I | - |
dc.subject.keywordPlus | IMMUNOTHERAPY | - |
dc.subject.keywordPlus | ANTIGEN | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | AML | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordAuthor | acute myeloid leukemia | - |
dc.subject.keywordAuthor | cytotoxic T cells | - |
dc.subject.keywordAuthor | extracellular nanovesicles | - |
dc.subject.keywordAuthor | iNKT cells | - |
dc.subject.keywordAuthor | memory immunity | - |
dc.subject.keywordAuthor | personalized vaccines | - |
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