Recovery of water-soluble bioactive components from defatted sesame meal using carbon dioxide assisted hydrothermal process

Abstract

Defatted sesame meal (DSM) is a source rich in glycosylated lignans and bioactive compounds. Hydrothermal (HT) processes with and without added CO2 were applied to recover these bioactive compounds. The extractions were performed from 120 to 180 degrees C with a solid-to-solvent ratio of 1:20 (w/w). The bioactivities, expressed in terms of the total phenol (TP) and total flavonoid (TF) contents in the HT extracts were enhanced 5- and 2.5-fold, respectively. The addition of CO2 enabled the recovery of more bioactive compounds with better antioxidant activities than those obtained using conventional extraction methods. In-vitro antioxidant and anticancer effects were evaluated for both the HT extracts and conventional extracts, where promising anticancer activity was observed with little effect on normal cells. (C) 2020 Elsevier B.V. All rights reserved.