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Umbilical Cord Mesenchymal Stem Cell-Derived Nanovesicles Potentiate the Bone-Formation Efficacy of Bone Morphogenetic Protein 2
DC Field | Value | Language |
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dc.contributor.author | Lim, Songhyun | - |
dc.contributor.author | Lyu, Hao-Zhen | - |
dc.contributor.author | Lee, Ju-Ro | - |
dc.contributor.author | Han, Shi Huan | - |
dc.contributor.author | Lee, Jae Hyup | - |
dc.contributor.author | Kim, Byung-Soo | - |
dc.date.accessioned | 2024-06-13T02:11:29Z | - |
dc.date.available | 2024-06-13T02:11:29Z | - |
dc.date.created | 2020-10-07 | - |
dc.date.created | 2020-10-07 | - |
dc.date.issued | 2020-09 | - |
dc.identifier.citation | International Journal of Molecular Sciences, Vol.21 No.17, pp.6425-16 | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.uri | https://hdl.handle.net/10371/204236 | - |
dc.description.abstract | Recombinant human bone morphogenetic protein 2 (rhBMP-2) is one of the most potent osteogenic factors used to treat bone loss. However, at higher doses, rhBMP-2 does not necessarily increase bone formation but rather increases the incidence of adverse side effects. Here, we investigated whether umbilical cord mesenchymal stem cell (UCMSC)-derived nanovesicles (NVs) further increase the in vivo bone formation at high doses of rhBMP-2. In the presence of UCMSC-derived NVs, proliferation, migration, and tube formation of human umbilical vein endothelial cells were stimulated in vitro. Furthermore, migration and osteogenesis of human bone marrow-derived mesenchymal stem cells were stimulated. To examine the efficacy of UCMSC-derived NVs on in vivo bone formation, collagen sponges soaked with rhBMP-2 and UCMSC-derived NVs were used in athymic nude mice with calvarial defects. At a high rhBMP-2 dosage (500 ng/mL), UCMSC-derived NVs significantly promoted bone formation in calvarial defects; however, the UCMSC-derived NVs alone did not induce in vivo bone formation. Our results indicate that UCMSC-derived NVs can potentiate the bone formation efficacy of rhBMP-2 at a high dosage. | - |
dc.language | 영어 | - |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | - |
dc.title | Umbilical Cord Mesenchymal Stem Cell-Derived Nanovesicles Potentiate the Bone-Formation Efficacy of Bone Morphogenetic Protein 2 | - |
dc.type | Article | - |
dc.identifier.doi | 10.3390/ijms21176425 | - |
dc.citation.journaltitle | International Journal of Molecular Sciences | - |
dc.identifier.wosid | 000570382900001 | - |
dc.identifier.scopusid | 2-s2.0-85090751303 | - |
dc.citation.endpage | 16 | - |
dc.citation.number | 17 | - |
dc.citation.startpage | 6425 | - |
dc.citation.volume | 21 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Lee, Jae Hyup | - |
dc.contributor.affiliatedAuthor | Kim, Byung-Soo | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | COLLAGEN SPONGE | - |
dc.subject.keywordPlus | DUAL DELIVERY | - |
dc.subject.keywordPlus | PROMOTE ANGIOGENESIS | - |
dc.subject.keywordPlus | GROWTH-FACTOR | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | REGENERATION | - |
dc.subject.keywordPlus | BMP-2 | - |
dc.subject.keywordPlus | EXOSOMES | - |
dc.subject.keywordPlus | MICROVESICLES | - |
dc.subject.keywordPlus | VEGF | - |
dc.subject.keywordAuthor | recombinant human bone morphogenetic protein 2 | - |
dc.subject.keywordAuthor | umbilical cord mesenchymal stem cell-derived nanovesicles | - |
dc.subject.keywordAuthor | bone formation | - |
dc.subject.keywordAuthor | angiogenesis | - |
dc.subject.keywordAuthor | osteogenesis | - |
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