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Comprehensive study on the formation mechanism of highly bioactive compounds from Allium hookeri root using subcritical water and their antioxidant and anticancer effects

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dc.contributor.authorMyint, Aye Aye-
dc.contributor.authorAregay, Mulugeta G.-
dc.contributor.authorKang, Mikyung-
dc.contributor.authorKim, Byung-Soo-
dc.contributor.authorLee, Youn-Woo-
dc.contributor.authorKim, Jaehoon-
dc.date.accessioned2024-06-13T02:11:45Z-
dc.date.available2024-06-13T02:11:45Z-
dc.date.created2020-05-15-
dc.date.created2020-05-15-
dc.date.issued2020-03-
dc.identifier.citationJournal of Supercritical Fluids, Vol.157, p. 104709-
dc.identifier.issn0896-8446-
dc.identifier.urihttps://hdl.handle.net/10371/204241-
dc.description.abstractWe report the efficiency of green subcritical water extraction (SWE) for the recovery of bioactive compounds from Allium hookeri root (AHR). The highest extraction yield (88 wt%) and highest contents of bioactive compounds including total phenolic content (29.4 mg of gallic acid equivalent/g of dry AHR), total flavonoid content (30.6 mg of quercetin equivalent/g of dry AHR), ascorbic acid (81 mg/g of dry AHR), and gallic acid (2.8 mg/g of dry AHR), as well as high concentrations of Maillard reaction products (melanoidins), and various rare sugars were achieved at 160 degrees C for 30 min. The SWE extracts possessed 89.3-91.8 % higher antioxidant activities than those of the Soxhlet water extract. As a result, the SWE extract showed strong anticancer effects against human cancer cells of the HT-1080 (fibrosarcoma) and MDA-MB-231 (breast cancer) cell lines, suggesting the possible application of the AHR extract obtained via SWE in cancer therapy and prevention. (C) 2019 Elsevier B.V. All rights reserved.-
dc.language영어-
dc.publisherElsevier BV-
dc.titleComprehensive study on the formation mechanism of highly bioactive compounds from Allium hookeri root using subcritical water and their antioxidant and anticancer effects-
dc.typeArticle-
dc.identifier.doi10.1016/j.supflu.2019.104709-
dc.citation.journaltitleJournal of Supercritical Fluids-
dc.identifier.wosid000514012800009-
dc.identifier.scopusid2-s2.0-85076150471-
dc.citation.startpage104709-
dc.citation.volume157-
dc.description.isOpenAccessN-
dc.contributor.affiliatedAuthorKim, Byung-Soo-
dc.contributor.affiliatedAuthorLee, Youn-Woo-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.subject.keywordPlusMAILLARD REACTION-PRODUCTS-
dc.subject.keywordPlusPRESSURIZED LIQUID EXTRACTION-
dc.subject.keywordPlusCOLOR CHANGES-
dc.subject.keywordPlusGINSENG-
dc.subject.keywordPlusCOMPONENTS-
dc.subject.keywordPlusFRUCTOSE-
dc.subject.keywordPlusPLANTS-
dc.subject.keywordPlusONION-
dc.subject.keywordPlusFOOD-
dc.subject.keywordPlusMRPS-
dc.subject.keywordAuthorAllium hookeri-
dc.subject.keywordAuthorGreen extraction technique-
dc.subject.keywordAuthorMelanoidins-
dc.subject.keywordAuthorRare sugars-
dc.subject.keywordAuthorAntioxidant activity-
dc.subject.keywordAuthorAnticancer effects-
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  • School of Chemical and Biological Engineering
Research Area biomaterials, nanomedicine, regenerative medicine

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