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Therapeutic Angiogenesis via Solar Cell-Facilitated Electrical Stimulation

Cited 27 time in Web of Science Cited 30 time in Scopus
Authors

Jeong, Gun-Jae; Oh, Jin Young; Kim, Yeon-Ju; Bhang, Suk Ho; Jang, Hyeon-Ki; Han, Jin; Yoon, Jeong-Kee; Kwon, Sang-Mo; Lee, Tae Ii; Kim, Byung-Soo

Issue Date
2017-11
Publisher
American Chemical Society
Citation
ACS Applied Materials and Interfaces, Vol.9 No.44, pp.38344-38355
Abstract
Cell therapy has been suggested as a treatment modality for ischemic diseases, but the poor survival and engraftment of implanted cells limit its therapeutic efficacy. To overcome such limitation, we used electrical stimulation (ES) derived from a wearable solar cell for inducing angiogenesis in ischemic tissue. ES enhanced the secretion of angiogenic growth factors and the migration of mesenchymal stem cells (MSCs), myoblasts, endothelial progenitor cells, and endothelial cells in vitro. In a mouse ischemic hindlimb model, ES generated by a solar cell and applied to the ischemic region promoted migration of MSCs toward the ischemic site and upregulated expression of angiogenic paracrine factors (vascular endothelial, basic fibroblast, and hepatocyte growth factors; and stromal cell-derived factor-l alpha). Importantly, solar cell-generated ES promoted the formation of capillaries and arterioles at the ischemic region, attenuated muscle necrosis and fibrosis, and eventually prevented loss of the ischemic limb. Solar cell ES therapy showed higher angiogenic efficacy than conventional MSC therapy. This study shows the feasibility of using solar cell ES as a novel treatment for therapeutic angiogenesis.
ISSN
1944-8244
URI
https://hdl.handle.net/10371/204259
DOI
https://doi.org/10.1021/acsami.7b13322
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  • College of Engineering
  • School of Chemical and Biological Engineering
Research Area biomaterials, nanomedicine, regenerative medicine

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