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Stretchable Piezoelectric Substrate Providing Pulsatile Mechanoelectric Cues for Cardiomyogenic Differentiation of Mesenchymal Stem Cells

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dc.contributor.authorYoon, Jeong-Kee-
dc.contributor.authorLee, Tae Il-
dc.contributor.authorBhang, Suk Ho-
dc.contributor.authorShin, Jung-Youn-
dc.contributor.authorMyoung, Jae-Min-
dc.contributor.authorKim, Byung Soo-
dc.date.accessioned2024-06-13T02:12:58Z-
dc.date.available2024-06-13T02:12:58Z-
dc.date.created2018-06-19-
dc.date.issued2017-07-
dc.identifier.citationACS Applied Materials and Interfaces, Vol.9 No.27, pp.22101-22111-
dc.identifier.issn1944-8244-
dc.identifier.urihttps://hdl.handle.net/10371/204264-
dc.description.abstractEx vivo induction of cardiomyogenic differentiation of mesenchymal stem cells (MSCs) before implantation would composite NRs aligned NRs potentiate therapeutic efficacy of stem cell therapies for ischemic heart diseases because MSCs rarely undergo cardiomyogenic differentiation following implantation. In cardiac microenvironments, electric pulse and cyclic mechanical strain are sequentially produced. However, no study has applied the pulsatile mechanoelectric cues (PMEC) to stimulate cardiomyogenic differentiation of MSCs ex vivo. In this study, we developed a stretchable piezoelectric substrate (SPS) that can provide PMEC to human MSCs (hMSCs) for cardiomyogenic differentiation ex vivo. Our data showed that hMSCs subjected to PMEC by SPS underwent promoted cardiac phenotype development: cell alignment and the expression of cardiac markers (i.e., cardiac transcription factors, structural proteins, ion channel proteins, and gap junction proteins). The enhanced cardiac phenotype development was mediated by the upregulation of cardiomyogenic differentiation-related autocrine factor expression, focal adhesion kinase, and extracellular signal-regulated kinases signaling pathways. Thus, SPS providing electrical and mechanical regulation of stem cells may be utilized to potentiate hMSC therapies for myocardial infarction and provide a tool for the study of stem cell biology.-
dc.language영어-
dc.publisherAmerican Chemical Society-
dc.titleStretchable Piezoelectric Substrate Providing Pulsatile Mechanoelectric Cues for Cardiomyogenic Differentiation of Mesenchymal Stem Cells-
dc.typeArticle-
dc.identifier.doi10.1021/acsami.7b03050-
dc.citation.journaltitleACS Applied Materials and Interfaces-
dc.identifier.wosid000405764700005-
dc.identifier.scopusid2-s2.0-85023782732-
dc.citation.endpage22111-
dc.citation.number27-
dc.citation.startpage22101-
dc.citation.volume9-
dc.description.isOpenAccessN-
dc.contributor.affiliatedAuthorKim, Byung Soo-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.subject.keywordPlusSMOOTH-MUSCLE-CELLS-
dc.subject.keywordPlusCARDIAC TRANSCRIPTION FACTORS-
dc.subject.keywordPlusMARROW STROMAL CELLS-
dc.subject.keywordPlusCYCLIC STRETCH-
dc.subject.keywordPlusELECTRICAL-STIMULATION-
dc.subject.keywordPlusINFARCTED MYOCARDIUM-
dc.subject.keywordPlusMECHANICAL STRETCH-
dc.subject.keywordPlusFIELD STIMULATION-
dc.subject.keywordPlusGENE-EXPRESSION-
dc.subject.keywordPlusHEART FUNCTION-
dc.subject.keywordAuthorcardiomyogenic differentiation-
dc.subject.keywordAuthorelectric pulse-
dc.subject.keywordAuthormechanical strain-
dc.subject.keywordAuthormesenchymal stem cell-
dc.subject.keywordAuthorpiezoelectric-
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  • College of Engineering
  • School of Chemical and Biological Engineering
Research Area biomaterials, nanomedicine, regenerative medicine

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