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Integration of mesenchymal stem cells with nanobiomaterials for the repair of myocardial infarction

Cited 28 time in Web of Science Cited 32 time in Scopus
Authors

Han, Jin; Park, Jooyeon; Kim, Byung-Soo

Issue Date
2015-12
Publisher
Elsevier BV
Citation
Advanced Drug Delivery Reviews, Vol.95, pp.15-28
Abstract
The integration of nanobiomaterials with stem cells represents a promising strategy for the treatment of myocardial infarction. While stem cells and nanobiomaterials each demonstrated partial success in cardiac repair individually, the therapeutic efficacy of the clinical settings for each of these has been low. Hence, a combination of nanobiomaterials with stem cells is vigorously studied to create synergistic effects for treating myocardial infarction. To date, various types of nanomaterials have been incorporated with stem cells to control cell fate, modulate the therapeutic behavior of stem cells, and make them more suitable for cardiac repair. Here, we review the current stem cell therapies for cardiac repair and describe the combinatorial approaches of using nanobiomaterials and stem cells to improve therapeutic efficacy for the treatment of myocardial infarction. (C) 2015 Elsevier B.V. All rights reserved.
ISSN
0169-409X
URI
https://hdl.handle.net/10371/204277
DOI
https://doi.org/10.1016/j.addr.2015.09.002
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  • College of Engineering
  • School of Chemical and Biological Engineering
Research Area biomaterials, nanomedicine, regenerative medicine

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