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Reduction of Adipose Tissue Formation by the Controlled Release of BMP-2 Using a Hydroxyapatite-Coated Collagen Carrier System for Sinus-Augmentation/Extraction-Socket Grafting
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Jung-Seok | - |
dc.contributor.author | Kim, Tae-Wan | - |
dc.contributor.author | Park, Soyon | - |
dc.contributor.author | Kim, Byung-Soo | - |
dc.contributor.author | Im, Gun-Il | - |
dc.contributor.author | Cho, Kyoo-Sung | - |
dc.contributor.author | Kim, Chang-Sung | - |
dc.date.accessioned | 2024-06-13T02:13:43Z | - |
dc.date.available | 2024-06-13T02:13:43Z | - |
dc.date.created | 2018-01-10 | - |
dc.date.created | 2018-01-10 | - |
dc.date.issued | 2015-11 | - |
dc.identifier.citation | Materials, Vol.8 No.11, pp.7634-7649 | - |
dc.identifier.issn | 1996-1944 | - |
dc.identifier.uri | https://hdl.handle.net/10371/204278 | - |
dc.description.abstract | The effects of hydroxyapatite (HA)-coating onto collagen carriers for application of recombinant human bone morphogenetic protein 2 (rhBMP-2) on cell differentiation in vitro, and on in vivo healing patterns after sinus-augmentation and alveolar socket-grafting were evaluated. In vitro induction of osteogenic/adipogenic differentiation was compared between the culture media with rhBMP-2 solution and with the released rhBMP-2 from the control collagen and from the HA-coated collagen. Demineralized bovine bone and collagen/HA-coated collagen were grafted with/without rhBMP-2 in sinus-augmentation and tooth-extraction-socket models. Adipogenic induction by rhBMP-2 released from HA-coated collagen was significantly reduced compared to collagen. In the sinus-augmentation model, sites that received rhBMP-2 exhibited large amounts of vascular tissue formation at two weeks and increased adipose tissue formation at eight weeks; this could be significantly reduced by using HA-coated collagen as a carrier for rhBMP-2. In extraction-socket grafting, dimensional reduction of alveolar ridge was significantly decreased at sites received rhBMP-2 compared to control sites, but adipose tissue was increased within the regenerated socket area. In conclusion, HA-coated collagen carrier for Escherichia coli-derived rhBMP-2 (ErhBMP-2) may reduce in vitro induction of adipogenic differentiation and in vivo adipose bone marrow tissue formation in bone tissue engineering by ErhBMP-2. | - |
dc.language | 영어 | - |
dc.publisher | MDPI Open Access Publishing | - |
dc.title | Reduction of Adipose Tissue Formation by the Controlled Release of BMP-2 Using a Hydroxyapatite-Coated Collagen Carrier System for Sinus-Augmentation/Extraction-Socket Grafting | - |
dc.type | Article | - |
dc.identifier.doi | 10.3390/ma8115411 | - |
dc.citation.journaltitle | Materials | - |
dc.identifier.wosid | 000365924500033 | - |
dc.identifier.scopusid | 2-s2.0-84949663613 | - |
dc.citation.endpage | 7649 | - |
dc.citation.number | 11 | - |
dc.citation.startpage | 7634 | - |
dc.citation.volume | 8 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Kim, Byung-Soo | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | BONE MORPHOGENETIC PROTEIN-2 | - |
dc.subject.keywordPlus | HEPARIN-CONJUGATED FIBRIN | - |
dc.subject.keywordPlus | ALVEOLAR RIDGE | - |
dc.subject.keywordPlus | SPINAL-FUSION | - |
dc.subject.keywordPlus | DEFECT MODEL | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordPlus | RHBMP-2 | - |
dc.subject.keywordPlus | REGENERATION | - |
dc.subject.keywordPlus | EXTRACTION | - |
dc.subject.keywordAuthor | bone morphogenetic protein | - |
dc.subject.keywordAuthor | collagen | - |
dc.subject.keywordAuthor | hydroxyapatite | - |
dc.subject.keywordAuthor | drug delivery system | - |
dc.subject.keywordAuthor | bone regeneration | - |
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