Publications

Detailed Information

Apatite-Coated Collagen Sponge for the Delivery of Bone Morphogenetic Protein-2 in Rabbit Posterolateral Lumbar Fusion

Cited 6 time in Web of Science Cited 7 time in Scopus
Authors

Koo, Ki Hyoung; Ahn, Jung Min; Lee, Jong Min; Kim, Byung-Soo; Kim, Chang-Sung; Im, Gun-Il

Issue Date
2014-10
Publisher
Blackwell Publishing Inc.
Citation
Artificial Organs, Vol.38 No.10, pp.893-899
Abstract
Bone morphogenetic proteins (BMPs) need an effective delivery system for efficient bone regeneration. In this study, we evaluated the efficiency of an apatite-coated collagen sponge for the long-term delivery of BMP-2 in a rabbit model of lumbar posterolateral fusion. A total of 15 rabbits, divided into three groups, underwent posterolateral lumbar fusion. The first group (control group) received uncoated collagen sponges without BMP-2. The second group (uncoated group) received uncoated collagen sponges with BMP-2 (40 mu g each side). The third group (apatite-coated group) received apatite-coated collagen sponges with the same level of BMPs (40 mu g each side). All rabbits were euthanized 6 weeks after operation, and the fusion status was assessed by radiographic study, micro-CT, manual palpation, biomechanical study, and histological examination. Fusion rates as determined by radiographic study, micro-CT, and manual palpation showed that the apatite-coated group had a significantly higher rate of fusion than the control group (P = 0.024), while the uncoated group did not (P = 0.083). Biomechanical study showed significantly higher tensile strength in the apatite-coated group than the uncoated group (P = 0.032). Denser trabeculations were found in the apatite-coated group compared with the uncoated group. It is concluded that the use of apatite-coated collagen sponges for BMP-2 delivery enhanced bone regeneration.
ISSN
0160-564X
URI
https://hdl.handle.net/10371/204292
DOI
https://doi.org/10.1111/aor.12249
Files in This Item:
There are no files associated with this item.
Appears in Collections:

Related Researcher

  • College of Engineering
  • School of Chemical and Biological Engineering
Research Area biomaterials, nanomedicine, regenerative medicine

Altmetrics

Item View & Download Count

  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Share