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Hyaluronate-Gold Nanoparticle/Tocilizumab Complex for the Treatment of Rheumatoid Arthritis

DC Field Value Language
dc.contributor.authorLee, Hwiwon-
dc.contributor.authorLee, Min-Young-
dc.contributor.authorBhang, Suk Ho-
dc.contributor.authorKim, Byung-Soo-
dc.contributor.authorKim, Yun Seop-
dc.contributor.authorJu, Ji Hyeon-
dc.contributor.authorKim, Ki Su-
dc.contributor.authorHahn, Sei Kwang-
dc.date.accessioned2024-06-13T02:14:35Z-
dc.date.available2024-06-13T02:14:35Z-
dc.date.created2018-06-19-
dc.date.created2018-06-19-
dc.date.issued2014-05-
dc.identifier.citationACS Nano, Vol.8 No.5, pp.4790-4798-
dc.identifier.issn1936-0851-
dc.identifier.urihttps://hdl.handle.net/10371/204294-
dc.description.abstractRheumatoid arthritis (RA) is a chronic inflammatory immune disease causing the inflammation of synovial membrane and the articular cartilage destruction. In this work, hyaluronate gold nanoparticle/Tocilizumab (HA-AuNP/TCZ) complex was prepared for the treatment of RA. AuNP was used as a drug carrier with antiangiogenic effect. in is a humanized monoclonal antibody against the interleukin-6 (IL-6) receptor and used as an immunosuppressive drug by Interfering IL-6 in the pathogenesis of RA. HA is known to have cartilage-protective and lubricant effects. HA was modified with cystamine via reductive amination, which was reduced with dithiothreitol (DTT) to prepare end-group thiolated HA (HA-SH). AuNP was chemically modified with HA-SH and physically modified with T. The formation of HA-AuNP/TCZ complex was corroborated by UV-vis spectroscopy, dynamic light scattering (DLS), and transmission electron microscopy (TEM). The therapeutic effect of HA-AuNP/TCZ complex on RA was confirmed In collagen-induced arthritis (CIA) model mice by ELISA, histological, and Western blot analyses.-
dc.language영어-
dc.publisherAmerican Chemical Society-
dc.titleHyaluronate-Gold Nanoparticle/Tocilizumab Complex for the Treatment of Rheumatoid Arthritis-
dc.typeArticle-
dc.identifier.doi10.1021/nn500685h-
dc.citation.journaltitleACS Nano-
dc.identifier.wosid000336640600069-
dc.identifier.scopusid2-s2.0-84901649576-
dc.citation.endpage4798-
dc.citation.number5-
dc.citation.startpage4790-
dc.citation.volume8-
dc.description.isOpenAccessN-
dc.contributor.affiliatedAuthorKim, Byung-Soo-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.subject.keywordPlusCOLLAGEN-INDUCED ARTHRITIS-
dc.subject.keywordPlusRECEPTOR INHIBITION-
dc.subject.keywordPlusNANOPARTICLES-
dc.subject.keywordPlusTOCILIZUMAB-
dc.subject.keywordPlusTHERAPY-
dc.subject.keywordPlusACID-
dc.subject.keywordPlusDISEASE-
dc.subject.keywordAuthorgold nanoparticle-
dc.subject.keywordAuthortocilizumab-
dc.subject.keywordAuthorhyaluronic acid-
dc.subject.keywordAuthordrug delivery-
dc.subject.keywordAuthorrheumatoid arthritis-
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  • College of Engineering
  • School of Chemical and Biological Engineering
Research Area biomaterials, nanomedicine, regenerative medicine

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