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Hyaluronate-Gold Nanoparticle/Tocilizumab Complex for the Treatment of Rheumatoid Arthritis
DC Field | Value | Language |
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dc.contributor.author | Lee, Hwiwon | - |
dc.contributor.author | Lee, Min-Young | - |
dc.contributor.author | Bhang, Suk Ho | - |
dc.contributor.author | Kim, Byung-Soo | - |
dc.contributor.author | Kim, Yun Seop | - |
dc.contributor.author | Ju, Ji Hyeon | - |
dc.contributor.author | Kim, Ki Su | - |
dc.contributor.author | Hahn, Sei Kwang | - |
dc.date.accessioned | 2024-06-13T02:14:35Z | - |
dc.date.available | 2024-06-13T02:14:35Z | - |
dc.date.created | 2018-06-19 | - |
dc.date.created | 2018-06-19 | - |
dc.date.issued | 2014-05 | - |
dc.identifier.citation | ACS Nano, Vol.8 No.5, pp.4790-4798 | - |
dc.identifier.issn | 1936-0851 | - |
dc.identifier.uri | https://hdl.handle.net/10371/204294 | - |
dc.description.abstract | Rheumatoid arthritis (RA) is a chronic inflammatory immune disease causing the inflammation of synovial membrane and the articular cartilage destruction. In this work, hyaluronate gold nanoparticle/Tocilizumab (HA-AuNP/TCZ) complex was prepared for the treatment of RA. AuNP was used as a drug carrier with antiangiogenic effect. in is a humanized monoclonal antibody against the interleukin-6 (IL-6) receptor and used as an immunosuppressive drug by Interfering IL-6 in the pathogenesis of RA. HA is known to have cartilage-protective and lubricant effects. HA was modified with cystamine via reductive amination, which was reduced with dithiothreitol (DTT) to prepare end-group thiolated HA (HA-SH). AuNP was chemically modified with HA-SH and physically modified with T. The formation of HA-AuNP/TCZ complex was corroborated by UV-vis spectroscopy, dynamic light scattering (DLS), and transmission electron microscopy (TEM). The therapeutic effect of HA-AuNP/TCZ complex on RA was confirmed In collagen-induced arthritis (CIA) model mice by ELISA, histological, and Western blot analyses. | - |
dc.language | 영어 | - |
dc.publisher | American Chemical Society | - |
dc.title | Hyaluronate-Gold Nanoparticle/Tocilizumab Complex for the Treatment of Rheumatoid Arthritis | - |
dc.type | Article | - |
dc.identifier.doi | 10.1021/nn500685h | - |
dc.citation.journaltitle | ACS Nano | - |
dc.identifier.wosid | 000336640600069 | - |
dc.identifier.scopusid | 2-s2.0-84901649576 | - |
dc.citation.endpage | 4798 | - |
dc.citation.number | 5 | - |
dc.citation.startpage | 4790 | - |
dc.citation.volume | 8 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Kim, Byung-Soo | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | COLLAGEN-INDUCED ARTHRITIS | - |
dc.subject.keywordPlus | RECEPTOR INHIBITION | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | TOCILIZUMAB | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | ACID | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordAuthor | gold nanoparticle | - |
dc.subject.keywordAuthor | tocilizumab | - |
dc.subject.keywordAuthor | hyaluronic acid | - |
dc.subject.keywordAuthor | drug delivery | - |
dc.subject.keywordAuthor | rheumatoid arthritis | - |
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