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Controlled Delivery of Low-Dose Bone Morphogenetic Protein-2 Using Heparin-Conjugated Fibrin in the Posterolateral Lumbar Fusion of Rabbits
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Koo, Ki-Hyoung | - |
dc.contributor.author | Lee, Jong-Min | - |
dc.contributor.author | Ahn, Jung-Min | - |
dc.contributor.author | Kim, Byung-Soo | - |
dc.contributor.author | La, Wan-Geun | - |
dc.contributor.author | Kim, Chang-Sung | - |
dc.contributor.author | Im, Gun-Il | - |
dc.date.accessioned | 2024-06-13T02:15:11Z | - |
dc.date.available | 2024-06-13T02:15:11Z | - |
dc.date.created | 2018-06-19 | - |
dc.date.created | 2018-06-19 | - |
dc.date.issued | 2013-05 | - |
dc.identifier.citation | Artificial Organs, Vol.37 No.5, pp.487-494 | - |
dc.identifier.issn | 0160-564X | - |
dc.identifier.uri | https://hdl.handle.net/10371/204305 | - |
dc.description.abstract | The heparin-conjugated fibrin (HCF) system has been developed to deliver bone morphogenetic proteins (BMPs) for a long-term period and thus enhance bone regeneration. In the present study, we tested the effectiveness of the delivery system for spinal fusion with a very low dose of BMP-2. A total of 15 rabbits underwent posterolateral lumbar spine, divided into three groups. The control group received only collagen sponges without BMP-2, another group (BMP-only group) received collagen sponges loaded with BMP-2 (10g each side), and the last group (BMP/HCF group) received collagen sponges filled with HCF loaded with BMP-2 (10g each side). All animals were euthanized 8 weeks after surgery, and the fusion was assessed by radiographs, manual palpation, computed tomography scan, and mechanical testing. No case in the BMP/HCF group or in the control group achieved solid fusion, while all cases in BMP-only group showed evidence of solid fusion. BMP/HCF group had significantly lower fusion rate and tensile strength than BMP-only group at the dose of 10g of BMP-2. The HCF long-term delivery system with the low dose of BMP-2 (10g) is ineffective for the induction of lumbar posterolateral fusion in the rabbits. | - |
dc.language | 영어 | - |
dc.publisher | Blackwell Publishing Inc. | - |
dc.title | Controlled Delivery of Low-Dose Bone Morphogenetic Protein-2 Using Heparin-Conjugated Fibrin in the Posterolateral Lumbar Fusion of Rabbits | - |
dc.type | Article | - |
dc.identifier.doi | 10.1111/j.1525-1594.2012.01578.x | - |
dc.citation.journaltitle | Artificial Organs | - |
dc.identifier.wosid | 000318223900011 | - |
dc.identifier.scopusid | 2-s2.0-84876795036 | - |
dc.citation.endpage | 494 | - |
dc.citation.number | 5 | - |
dc.citation.startpage | 487 | - |
dc.citation.volume | 37 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Kim, Byung-Soo | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | SPINAL-FUSION | - |
dc.subject.keywordPlus | CONTROLLED-RELEASE | - |
dc.subject.keywordPlus | COLLAGEN SPONGE | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | RHBMP-2 | - |
dc.subject.keywordPlus | MODEL | - |
dc.subject.keywordPlus | REGENERATION | - |
dc.subject.keywordPlus | EFFICACY | - |
dc.subject.keywordPlus | MATRIX | - |
dc.subject.keywordPlus | ARTHRODESIS | - |
dc.subject.keywordAuthor | Bone morphogenetic protein-2 | - |
dc.subject.keywordAuthor | Long-term delivery system | - |
dc.subject.keywordAuthor | Heparin-conjugated fibrin | - |
dc.subject.keywordAuthor | Spine fusion | - |
dc.subject.keywordAuthor | Dose | - |
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