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Controlled Delivery of Low-Dose Bone Morphogenetic Protein-2 Using Heparin-Conjugated Fibrin in the Posterolateral Lumbar Fusion of Rabbits

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dc.contributor.authorKoo, Ki-Hyoung-
dc.contributor.authorLee, Jong-Min-
dc.contributor.authorAhn, Jung-Min-
dc.contributor.authorKim, Byung-Soo-
dc.contributor.authorLa, Wan-Geun-
dc.contributor.authorKim, Chang-Sung-
dc.contributor.authorIm, Gun-Il-
dc.date.accessioned2024-06-13T02:15:11Z-
dc.date.available2024-06-13T02:15:11Z-
dc.date.created2018-06-19-
dc.date.created2018-06-19-
dc.date.issued2013-05-
dc.identifier.citationArtificial Organs, Vol.37 No.5, pp.487-494-
dc.identifier.issn0160-564X-
dc.identifier.urihttps://hdl.handle.net/10371/204305-
dc.description.abstractThe heparin-conjugated fibrin (HCF) system has been developed to deliver bone morphogenetic proteins (BMPs) for a long-term period and thus enhance bone regeneration. In the present study, we tested the effectiveness of the delivery system for spinal fusion with a very low dose of BMP-2. A total of 15 rabbits underwent posterolateral lumbar spine, divided into three groups. The control group received only collagen sponges without BMP-2, another group (BMP-only group) received collagen sponges loaded with BMP-2 (10g each side), and the last group (BMP/HCF group) received collagen sponges filled with HCF loaded with BMP-2 (10g each side). All animals were euthanized 8 weeks after surgery, and the fusion was assessed by radiographs, manual palpation, computed tomography scan, and mechanical testing. No case in the BMP/HCF group or in the control group achieved solid fusion, while all cases in BMP-only group showed evidence of solid fusion. BMP/HCF group had significantly lower fusion rate and tensile strength than BMP-only group at the dose of 10g of BMP-2. The HCF long-term delivery system with the low dose of BMP-2 (10g) is ineffective for the induction of lumbar posterolateral fusion in the rabbits.-
dc.language영어-
dc.publisherBlackwell Publishing Inc.-
dc.titleControlled Delivery of Low-Dose Bone Morphogenetic Protein-2 Using Heparin-Conjugated Fibrin in the Posterolateral Lumbar Fusion of Rabbits-
dc.typeArticle-
dc.identifier.doi10.1111/j.1525-1594.2012.01578.x-
dc.citation.journaltitleArtificial Organs-
dc.identifier.wosid000318223900011-
dc.identifier.scopusid2-s2.0-84876795036-
dc.citation.endpage494-
dc.citation.number5-
dc.citation.startpage487-
dc.citation.volume37-
dc.description.isOpenAccessN-
dc.contributor.affiliatedAuthorKim, Byung-Soo-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.subject.keywordPlusSPINAL-FUSION-
dc.subject.keywordPlusCONTROLLED-RELEASE-
dc.subject.keywordPlusCOLLAGEN SPONGE-
dc.subject.keywordPlusIN-VIVO-
dc.subject.keywordPlusRHBMP-2-
dc.subject.keywordPlusMODEL-
dc.subject.keywordPlusREGENERATION-
dc.subject.keywordPlusEFFICACY-
dc.subject.keywordPlusMATRIX-
dc.subject.keywordPlusARTHRODESIS-
dc.subject.keywordAuthorBone morphogenetic protein-2-
dc.subject.keywordAuthorLong-term delivery system-
dc.subject.keywordAuthorHeparin-conjugated fibrin-
dc.subject.keywordAuthorSpine fusion-
dc.subject.keywordAuthorDose-
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  • College of Engineering
  • School of Chemical and Biological Engineering
Research Area biomaterials, nanomedicine, regenerative medicine

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