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Volume-Stable Adipose Tissue Formation by Implantation of Human Adipose-Derived Stromal Cells Using Solid Free-Form Fabrication-Based Polymer Scaffolds

Cited 7 time in Web of Science Cited 9 time in Scopus
Authors

Lee, Tae-Jin; Bhang, Suk Ho; La, Wan-Guen; Kwon, Sun-Hyun; Shin, Jung-Youn; Yoon, Hee Hun; Shin, Heungsoo; Cho, Dong-Woo; Kim, Byung-Soo

Issue Date
2013-01
Publisher
Lippincott Williams & Wilkins Ltd.
Citation
Annals of Plastic Surgery, Vol.70 No.1, pp.98-102
Abstract
Regeneration of volume-stable adipose tissue is required for treatment of soft-tissue loss due to cancer, trauma, burns and for correctional cosmetic surgery. In this study, we hypothesized that transplantation of human adipose-derived stromal cells (hADSCs) using polycaprolactone (PCL) scaffolds fabricated with a solid free-form fabrication method would better maintain the volume of regenerated adipose tissues, as compared with the use of fibrin gel. Six weeks after implantation into the dorsal subcutaneous pockets of athymic mice, the volumes and adipose tissue areas of hADSC-PCL scaffold implants were significantly larger than those of hADSC-fibrin implants. In addition, the mRNA expression of adipogenic genes was more extensive in the hADSC-PCL scaffold implants.
ISSN
0148-7043
URI
https://hdl.handle.net/10371/204309
DOI
https://doi.org/10.1097/SAP.0b013e31822f9a81
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  • College of Engineering
  • School of Chemical and Biological Engineering
Research Area biomaterials, nanomedicine, regenerative medicine

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