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3,4-dihydroxy-L-phenylalanine as a cell adhesion molecule in serum-free cell culture

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dc.contributor.authorLa, Wan-Geun-
dc.contributor.authorBhang, Suk Ho-
dc.contributor.authorShin, Jung-Youn-
dc.contributor.authorYoon, Hee Hun-
dc.contributor.authorPark, Jooyeon-
dc.contributor.authorYang, Hee Seok-
dc.contributor.authorYu, Seung-Ho-
dc.contributor.authorSung, Yung-Eun-
dc.contributor.authorKim, Byung-Soo-
dc.date.accessioned2024-06-13T02:16:51Z-
dc.date.available2024-06-13T02:16:51Z-
dc.date.created2018-06-19-
dc.date.created2018-06-19-
dc.date.issued2012-07-
dc.identifier.citationBIOTECHNOLOGY PROGRESS, Vol.28 No.4, pp.1055-1060-
dc.identifier.issn8756-7938-
dc.identifier.urihttps://hdl.handle.net/10371/204320-
dc.description.abstractIn this article, we examined the feasibility of using 3,4-dihydroxy-L-phenylalanine (DOPA) as a cell adhesion molecule in serum-free cultures of anchorage-dependent mammalian cells. DOPA is a critical, functional element in mussel adhesive proteins and is known to bind strongly to various natural or synthetic materials. DOPA coating on culture plates was confirmed using X-ray photoelectron spectroscopy and energy-dispersive spectroscopy. Human dermal fibroblasts (HDFs) were cultured on DOPA-coated, fibronectin-coated, or no material-coated culture plates in serum-free medium. HDFs cultured on DOPA showed the highest cell adhesion ratio, spreading, and viability but the lowest apoptotic activity. Therefore, DOPA may be a useful cell-adhesion molecule for serum-free culture. (c) 2012 American Institute of Chemical Engineers Biotechnol. Prog., 28: 10551060, 2012-
dc.language영어-
dc.publisherWILEY-BLACKWELL-
dc.title3,4-dihydroxy-L-phenylalanine as a cell adhesion molecule in serum-free cell culture-
dc.typeArticle-
dc.identifier.doi10.1002/btpr.1560-
dc.citation.journaltitleBIOTECHNOLOGY PROGRESS-
dc.identifier.wosid000307220900020-
dc.identifier.scopusid2-s2.0-84864838061-
dc.citation.endpage1060-
dc.citation.number4-
dc.citation.startpage1055-
dc.citation.volume28-
dc.description.isOpenAccessN-
dc.contributor.affiliatedAuthorSung, Yung-Eun-
dc.contributor.affiliatedAuthorKim, Byung-Soo-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.subject.keywordPlusFIBROBLAST ATTACHMENT-
dc.subject.keywordPlusPROLIFERATION-
dc.subject.keywordPlusFIBRONECTIN-
dc.subject.keywordPlusPROTEINS-
dc.subject.keywordPlusSURFACES-
dc.subject.keywordPlusCHEMISTRY-
dc.subject.keywordPlusSURVIVAL-
dc.subject.keywordPlusBEHAVIOR-
dc.subject.keywordAuthorcell adhesion-
dc.subject.keywordAuthorcell adhesion molecule-
dc.subject.keywordAuthordermal fibroblasts-
dc.subject.keywordAuthor3-
dc.subject.keywordAuthor4-dihydroxy-L-phenylalanine-
dc.subject.keywordAuthorserum-free culture-
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  • College of Engineering
  • School of Chemical and Biological Engineering
Research Area biomaterials, nanomedicine, regenerative medicine

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