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Long-term angiogenesis efficacy using a heparin-conjugated fibrin (HCF) delivery system with HBM-MSCs
DC Field | Value | Language |
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dc.contributor.author | Kim, A.-K. | - |
dc.contributor.author | Kim, M.-H. | - |
dc.contributor.author | Kim, B.-S. | - |
dc.contributor.author | Kim, D.-I. | - |
dc.date.accessioned | 2024-06-13T02:17:04Z | - |
dc.date.available | 2024-06-13T02:17:04Z | - |
dc.date.created | 2023-05-19 | - |
dc.date.created | 2023-05-19 | - |
dc.date.issued | 2012-05 | - |
dc.identifier.citation | International Journal of Stem Cells, Vol.5 No.1, pp.23-30 | - |
dc.identifier.issn | 2005-3606 | - |
dc.identifier.uri | https://hdl.handle.net/10371/204324 | - |
dc.description.abstract | Background and Objectives: Heparin-conjugated fibrin (HCF) is suitable for the release and localization of bFGF. We analyzed the effects of a bFGF delivery system using HCF with human bone marrow-derived mesenchymal stem cells (HBM- MSCs) in a dog ischemic limb model. Methods and Results: Animals were divided into HBM-MSCs, HBM-MSCs+HCF, bFGF-HCF, and HBM-MSCs+ bFGF-HCF groups. A total of 1×107 HBM-MSCs were injected per animal, and the amount of bFGF was 1 mg per dog. Ischemic muscles were harvested at eight weeks and six months after injection of cells. The HBM-MSCs+ bFGF-HCF group exhibited decreased proportions of capillaries and arterioles six months after transplantation. However, there were more cells positive for the angiogenic factors, VEGF and PDGF, in the eight-week specimens compared with those harvested six months after transplantation. Conclusions: Our results demonstrated that a single injection of HBM-MSCs did not have significant long-term angiogenic effects; however, a bFGF delivery system using HCF exerted prolonged angiogenic effects when combined with HBM-MSCs. | - |
dc.language | 영어 | - |
dc.publisher | Korean Society for Stem Cell Research | - |
dc.title | Long-term angiogenesis efficacy using a heparin-conjugated fibrin (HCF) delivery system with HBM-MSCs | - |
dc.type | Article | - |
dc.citation.journaltitle | International Journal of Stem Cells | - |
dc.identifier.scopusid | 2-s2.0-84875255422 | - |
dc.citation.endpage | 30 | - |
dc.citation.number | 1 | - |
dc.citation.startpage | 23 | - |
dc.citation.volume | 5 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Kim, B.-S. | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordAuthor | Angiogenesis | - |
dc.subject.keywordAuthor | HBM-MSCs | - |
dc.subject.keywordAuthor | Heparin-conjugated fibrin | - |
dc.subject.keywordAuthor | Ischemia | - |
dc.subject.keywordAuthor | Vascular disease | - |
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