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The effect of platelet rich plasma from bone marrow aspirate with added bone morphogenetic protein-2 on the achilles tendon-bone junction in Rabbits
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hak Jun Kim | - |
dc.contributor.author | Hyok-Woo Nam | - |
dc.contributor.author | Chang-Yong Hur | - |
dc.contributor.author | Misu Park | - |
dc.contributor.author | Hee Seok Yang | - |
dc.contributor.author | Byung-Soo Kim | - |
dc.contributor.author | Jung-Ho Park | - |
dc.date.accessioned | 2024-06-13T02:17:27Z | - |
dc.date.available | 2024-06-13T02:17:27Z | - |
dc.date.created | 2018-06-21 | - |
dc.date.created | 2018-06-21 | - |
dc.date.issued | 2011-12 | - |
dc.identifier.citation | Clinics in Orthopedic Surgery, Vol.3 No.4, pp.325-331 | - |
dc.identifier.issn | 2005-291x | - |
dc.identifier.uri | https://hdl.handle.net/10371/204331 | - |
dc.description.abstract | Background: To determine if exogenously injected bone marrow derived platelet-rich plasma (PRP) plus bone morphogenetic protein (BMP)-2 could accelerate the healing of bone-tendon junction injuries and increase the junction holding strength during the early regeneration period. Methods: A direct injury model of the bone-tendon junction was made using an Achilles tendon-calcaneus bone junction in a rabbit. In the PRP/BMP-2/fibrin group, 0.05 mL of bone marrow derived PRP and 100 ng/mL of BMP-2 both incorporated into 0.1 mL of fibrin glue were injected into Achilles tendon-calcaneus bone junctions. The effect of the intervention was tested by comparing the results of an intervention group to a control group. The results of biomechanical testing, and histological and gross analyses were compared between the 2 groups at the following time points after surgery: 2 weeks, 4 weeks, and 8 weeks. Results: Histologic examinations showed that woven bone developed in tendon-bone junctions at 2 weeks after surgery in the PRP/BMP-2/fibrin group. Mechanical test results showed no significant difference between the PRP/BMP-2/fibrin and control groups at 2 and 4 weeks after surgery, but the mean maximal load in the PRP/BMP-2/fibrin group was significantly higher than in the control group (p < 0.05) at 8 weeks after surgery. Conclusions: Bone marrow derived PRP and BMP-2 in fibrin glue accelerated healing in a rabbit model of tendon-bone junction injury. © 2011 by The Korean Orthopaedic Association. | - |
dc.language | 영어 | - |
dc.publisher | 대한정형외과학회 | - |
dc.title | The effect of platelet rich plasma from bone marrow aspirate with added bone morphogenetic protein-2 on the achilles tendon-bone junction in Rabbits | - |
dc.type | Article | - |
dc.identifier.doi | 10.4055/cios.2011.3.4.325 | - |
dc.citation.journaltitle | Clinics in Orthopedic Surgery | - |
dc.identifier.scopusid | 2-s2.0-83255188688 | - |
dc.citation.endpage | 331 | - |
dc.citation.number | 4 | - |
dc.citation.startpage | 325 | - |
dc.citation.volume | 3 | - |
dc.identifier.kciid | ART001900866 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Byung-Soo Kim | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | bone morphogenetic protein 2 | - |
dc.subject.keywordPlus | fibrin glue | - |
dc.subject.keywordPlus | achilles tendinitis | - |
dc.subject.keywordPlus | achilles tendon | - |
dc.subject.keywordPlus | animal experiment | - |
dc.subject.keywordPlus | animal tissue | - |
dc.subject.keywordPlus | article | - |
dc.subject.keywordPlus | biomechanics | - |
dc.subject.keywordPlus | bone development | - |
dc.subject.keywordPlus | bone marrow biopsy | - |
dc.subject.keywordPlus | bone regeneration | - |
dc.subject.keywordPlus | calcaneus | - |
dc.subject.keywordPlus | controlled study | - |
dc.subject.keywordPlus | fracture healing | - |
dc.subject.keywordPlus | histology | - |
dc.subject.keywordPlus | male | - |
dc.subject.keywordPlus | mechanical stimulation | - |
dc.subject.keywordPlus | nonhuman | - |
dc.subject.keywordPlus | postoperative period | - |
dc.subject.keywordPlus | rabbit | - |
dc.subject.keywordPlus | thrombocyte rich plasma | - |
dc.subject.keywordPlus | weight bearing | - |
dc.subject.keywordPlus | Achilles Tendon | - |
dc.subject.keywordPlus | Animals | - |
dc.subject.keywordPlus | Bone Marrow | - |
dc.subject.keywordPlus | Bone Morphogenetic Protein 2 | - |
dc.subject.keywordPlus | Calcaneus | - |
dc.subject.keywordPlus | Male | - |
dc.subject.keywordPlus | Platelet-Rich Plasma | - |
dc.subject.keywordPlus | Rabbits | - |
dc.subject.keywordAuthor | Achilles tendon | - |
dc.subject.keywordAuthor | Bone marrow derived platelet rich plasma | - |
dc.subject.keywordAuthor | Bone morphogenetic protein | - |
dc.subject.keywordAuthor | Bone-tendon junction | - |
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