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Stem-cell Therapy for Peripheral Arterial Occlusive Disease
Cited 16 time in
Web of Science
Cited 20 time in Scopus
- Authors
- Issue Date
- 2011-11
- Publisher
- W. B. Saunders Co., Ltd.
- Citation
- European Journal of Vascular and Endovascular Surgery, Vol.42 No.5, pp.667-675
- Abstract
- Objective: The aims of our study were to confirm the effectiveness via animal study and safety through clinical trials of using human cord blood-mononuclear cells (HCB-MNCs). Design: We performed a dose-response animal study (HCB-MNCs: 4 x 10(6), 4 x 10(7) and 4 x 10(8)) using a limb ischaemia model in dogs to assess angiogenic responses. Safety assessment in humans in terms of graft-versus-host-disease was also done by observing an uncontrolled case series. Materials and methods: Twelve animal ischaemic limbs and seven patients with thromboangiitis obliterans were treated with HCB-MNCs. These cells (4 x 10(8)) were injected into the ischaemic limb muscle of patients. The results were analysed at 8 weeks for the animal study and at 6 months for patients. Results: In the animal ischaemic models, the number of capillaries, angiogenic gene expression and the angiogenic factors were increased after HCB-MNC injection. In the clinical study, the seven patients experienced no graft-versus-host-disease or cardiac/cerebral complications during the follow-up period. Conclusion: This preliminary study suggests that HCB-MNC might be a safe source of stem cells for treating ischaemic limbs. However, further clinical studies are needed to establish the long-term safety and the clinical efficacy of HCB-MNC transplantation in patients with ischaemic limbs. (C) 2011 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved.
- ISSN
- 1078-5884
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