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Enhanced skin wound healing by a sustained release of growth factors contained in platelet-rich plasma
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yang, Hee Seok | - |
dc.contributor.author | Shin, Jaehoon | - |
dc.contributor.author | Bhang, Suk Ho | - |
dc.contributor.author | Shin, Jung-Youn | - |
dc.contributor.author | Park, Jooyeon | - |
dc.contributor.author | Im, Gun-Il | - |
dc.contributor.author | Kim, Chang-Sung | - |
dc.contributor.author | Kim, Byung-Soo | - |
dc.date.accessioned | 2024-06-13T02:17:42Z | - |
dc.date.available | 2024-06-13T02:17:42Z | - |
dc.date.created | 2018-06-19 | - |
dc.date.created | 2018-06-19 | - |
dc.date.issued | 2011-11 | - |
dc.identifier.citation | EXPERIMENTAL AND MOLECULAR MEDICINE, Vol.43 No.11, pp.622-629 | - |
dc.identifier.issn | 1226-3613 | - |
dc.identifier.uri | https://hdl.handle.net/10371/204336 | - |
dc.description.abstract | Platelet-rich plasma (PAP) contains growth factors that promote tissue regeneration. Previously, we showed that heparin-conjugated fibrin (HCF) exerts the sustained release of growth factors with affinity for heparin. Here, we hypothesize that treatment of skin wound with a mixture of PAP and HCF exerts sustained release of several growth factors contained in PAP and promotes skin wound healing. The release of fibroblast growth factor 2, platelet-derived growth factor-BB, and vascular endothelial growth factor contained in PAP from HCF was sustained for a longer period than those from PAP, calcium-activated PRP (C-PAP), or a mixture of fibrin and PRP (F-PRP). Treatment of full-thickness skin wounds in mice with HCF-PRP resulted in much faster wound closure as well as dermal and epidermal regeneration at day 12 compared to treatment with either C-PRP or F-PRP. Enhanced skin regeneration observed in HCF-PRP group may have been at least partially due to enhanced angiogenesis in the wound beds. Therefore, this method could be useful for skin wound treatment. | - |
dc.language | 영어 | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | Enhanced skin wound healing by a sustained release of growth factors contained in platelet-rich plasma | - |
dc.type | Article | - |
dc.identifier.doi | 10.3858/emm.2011.43.11.070 | - |
dc.citation.journaltitle | EXPERIMENTAL AND MOLECULAR MEDICINE | - |
dc.identifier.wosid | 000297615300003 | - |
dc.identifier.scopusid | 2-s2.0-81855201882 | - |
dc.citation.endpage | 629 | - |
dc.citation.number | 11 | - |
dc.citation.startpage | 622 | - |
dc.citation.volume | 43 | - |
dc.identifier.kciid | ART001603403 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Kim, Byung-Soo | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | HEPARAN-SULFATE PROTEOGLYCANS | - |
dc.subject.keywordPlus | MATRIX METALLOPROTEINASES | - |
dc.subject.keywordPlus | ANGIOGENESIS | - |
dc.subject.keywordPlus | INTEGRIN | - |
dc.subject.keywordPlus | LOCALIZATION | - |
dc.subject.keywordPlus | STIMULATION | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | MIGRATION | - |
dc.subject.keywordPlus | GRAFTS | - |
dc.subject.keywordAuthor | angiogenesis inducing agents | - |
dc.subject.keywordAuthor | endothelial growth factors | - |
dc.subject.keywordAuthor | fibrin | - |
dc.subject.keywordAuthor | fibroblast growth factor 2 | - |
dc.subject.keywordAuthor | heparin | - |
dc.subject.keywordAuthor | neovascularization, physiologic | - |
dc.subject.keywordAuthor | platelet-derived growth factor | - |
dc.subject.keywordAuthor | platelet-rich plasma | - |
dc.subject.keywordAuthor | wound healing | - |
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