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Enhanced skin wound healing by a sustained release of growth factors contained in platelet-rich plasma

DC Field Value Language
dc.contributor.authorYang, Hee Seok-
dc.contributor.authorShin, Jaehoon-
dc.contributor.authorBhang, Suk Ho-
dc.contributor.authorShin, Jung-Youn-
dc.contributor.authorPark, Jooyeon-
dc.contributor.authorIm, Gun-Il-
dc.contributor.authorKim, Chang-Sung-
dc.contributor.authorKim, Byung-Soo-
dc.date.accessioned2024-06-13T02:17:42Z-
dc.date.available2024-06-13T02:17:42Z-
dc.date.created2018-06-19-
dc.date.created2018-06-19-
dc.date.issued2011-11-
dc.identifier.citationEXPERIMENTAL AND MOLECULAR MEDICINE, Vol.43 No.11, pp.622-629-
dc.identifier.issn1226-3613-
dc.identifier.urihttps://hdl.handle.net/10371/204336-
dc.description.abstractPlatelet-rich plasma (PAP) contains growth factors that promote tissue regeneration. Previously, we showed that heparin-conjugated fibrin (HCF) exerts the sustained release of growth factors with affinity for heparin. Here, we hypothesize that treatment of skin wound with a mixture of PAP and HCF exerts sustained release of several growth factors contained in PAP and promotes skin wound healing. The release of fibroblast growth factor 2, platelet-derived growth factor-BB, and vascular endothelial growth factor contained in PAP from HCF was sustained for a longer period than those from PAP, calcium-activated PRP (C-PAP), or a mixture of fibrin and PRP (F-PRP). Treatment of full-thickness skin wounds in mice with HCF-PRP resulted in much faster wound closure as well as dermal and epidermal regeneration at day 12 compared to treatment with either C-PRP or F-PRP. Enhanced skin regeneration observed in HCF-PRP group may have been at least partially due to enhanced angiogenesis in the wound beds. Therefore, this method could be useful for skin wound treatment.-
dc.language영어-
dc.publisherNATURE PUBLISHING GROUP-
dc.titleEnhanced skin wound healing by a sustained release of growth factors contained in platelet-rich plasma-
dc.typeArticle-
dc.identifier.doi10.3858/emm.2011.43.11.070-
dc.citation.journaltitleEXPERIMENTAL AND MOLECULAR MEDICINE-
dc.identifier.wosid000297615300003-
dc.identifier.scopusid2-s2.0-81855201882-
dc.citation.endpage629-
dc.citation.number11-
dc.citation.startpage622-
dc.citation.volume43-
dc.identifier.kciidART001603403-
dc.description.isOpenAccessY-
dc.contributor.affiliatedAuthorKim, Byung-Soo-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.subject.keywordPlusHEPARAN-SULFATE PROTEOGLYCANS-
dc.subject.keywordPlusMATRIX METALLOPROTEINASES-
dc.subject.keywordPlusANGIOGENESIS-
dc.subject.keywordPlusINTEGRIN-
dc.subject.keywordPlusLOCALIZATION-
dc.subject.keywordPlusSTIMULATION-
dc.subject.keywordPlusMECHANISMS-
dc.subject.keywordPlusINDUCTION-
dc.subject.keywordPlusMIGRATION-
dc.subject.keywordPlusGRAFTS-
dc.subject.keywordAuthorangiogenesis inducing agents-
dc.subject.keywordAuthorendothelial growth factors-
dc.subject.keywordAuthorfibrin-
dc.subject.keywordAuthorfibroblast growth factor 2-
dc.subject.keywordAuthorheparin-
dc.subject.keywordAuthorneovascularization, physiologic-
dc.subject.keywordAuthorplatelet-derived growth factor-
dc.subject.keywordAuthorplatelet-rich plasma-
dc.subject.keywordAuthorwound healing-
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  • College of Engineering
  • School of Chemical and Biological Engineering
Research Area biomaterials, nanomedicine, regenerative medicine

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