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Apatite-Coated Collagen Scaffold for Bone Morphogenetic Protein-2 Delivery

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dc.contributor.authorYang, Hee Seok-
dc.contributor.authorLa, Wan-Geun-
dc.contributor.authorBhang, Suk Ho-
dc.contributor.authorLee, Tae-Jin-
dc.contributor.authorLee, Minhyung-
dc.contributor.authorKim, Byung-Soo-
dc.date.accessioned2024-06-13T02:17:52Z-
dc.date.available2024-06-13T02:17:52Z-
dc.date.created2018-06-19-
dc.date.created2018-06-19-
dc.date.issued2011-09-
dc.identifier.citationTISSUE ENGINEERING PART A, Vol.17 No.17-18, pp.2153-2164-
dc.identifier.issn1937-3341-
dc.identifier.urihttps://hdl.handle.net/10371/204339-
dc.description.abstractBone morphogenetic proteins (BMPs) are the most potent osteoinductive growth factors. BMP-2 is clinically used for spine fusion and bone fracture healing. Commercially available BMP-2 uses a type I collagen scaffold as a carrier, but it only releases BMP-2 for a short period of time, which may release the bone formation efficacy. In the present study, we hypothesize that apatite coating of a collagen scaffold increases the release period as well as the osteogenic efficacy of BMP-2. Apatite coating was achieved by incubating collagen scaffolds in simulated body fluids (SBFs). Apatite coating on collagen scaffolds was confirmed by X-ray diffraction, electron spectroscopy for chemical analysis, attenuated total reflectance-Fourier transform infrared spectroscopy, and scanning electron microscopy. The rate and period of BMP-2 release from apatite-coated collagen scaffolds varied depending on the concentration of SBFs used. The 5x and 10x SBF apatite-coated collagen scaffolds released 91.8%+/- 11.5% and 82.2%+/- 13.1% of their loaded BMP-2 over 13 days in vitro, respectively, whereas noncoated collagen scaffold released 98.3%+/- 2.2% over the initial one day. BMP-2 released from apatite-coated collagen scaffold significantly increased the alkaline phosphatase activity of cultured osteoblasts, compared with BMP-2 released from noncoated collagen scaffold. Computed tomography and histomorphometry showed that BMP-2 delivery using apatite-coated collagen scaffolds resulted in 2.5-fold higher bone formation volume and 4.0-fold higher bone formation area than BMP-2 delivery using noncoated collagen scaffolds. This study shows that simple apatite coating of a collagen scaffold results in a BMP-2 carrier that renders long-term release of BMP-2 and dramatically enhances osteogenic efficacy.-
dc.language영어-
dc.publisherMARY ANN LIEBERT, INC-
dc.titleApatite-Coated Collagen Scaffold for Bone Morphogenetic Protein-2 Delivery-
dc.typeArticle-
dc.identifier.doi10.1089/ten.tea.2010.0702-
dc.citation.journaltitleTISSUE ENGINEERING PART A-
dc.identifier.wosid000294303700004-
dc.identifier.scopusid2-s2.0-80053166656-
dc.citation.endpage2164-
dc.citation.number17-18-
dc.citation.startpage2153-
dc.citation.volume17-
dc.description.isOpenAccessN-
dc.contributor.affiliatedAuthorKim, Byung-Soo-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.subject.keywordPlusMESENCHYMAL STEM-CELLS-
dc.subject.keywordPlusIN-VIVO-
dc.subject.keywordPlusCLINICAL-APPLICATIONS-
dc.subject.keywordPlusCONTROLLED-RELEASE-
dc.subject.keywordPlusSUSTAINED-RELEASE-
dc.subject.keywordPlusSTROMAL CELLS-
dc.subject.keywordPlusREGENERATION-
dc.subject.keywordPlusENHANCEMENT-
dc.subject.keywordPlusEFFICACY-
dc.subject.keywordPlusCARRIERS-
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  • College of Engineering
  • School of Chemical and Biological Engineering
Research Area biomaterials, nanomedicine, regenerative medicine

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