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Enhanced chondrogenic marker expression of human mesenchymal stem cells by interaction with both TGF-beta 3 and hyaluronic acid : Enhanced chondrogenic marker expression of human mesenchymal stem cells by interaction with both TGF-β3 and hyaluronic acid
DC Field | Value | Language |
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dc.contributor.author | Bhang, Suk Ho | - |
dc.contributor.author | Jeon, Jeong-Yi | - |
dc.contributor.author | La, Wan-Geun | - |
dc.contributor.author | Seong, Jun Yeup | - |
dc.contributor.author | Hwang, Jin Wook | - |
dc.contributor.author | Ryu, Seong Eon | - |
dc.contributor.author | Kim, Byung-Soo | - |
dc.date.accessioned | 2024-06-13T02:17:55Z | - |
dc.date.available | 2024-06-13T02:17:55Z | - |
dc.date.created | 2018-06-19 | - |
dc.date.created | 2018-06-19 | - |
dc.date.created | 2018-06-19 | - |
dc.date.issued | 2011-07 | - |
dc.identifier.citation | BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY, Vol.58 No.4, pp.271-276 | - |
dc.identifier.issn | 0885-4513 | - |
dc.identifier.uri | https://hdl.handle.net/10371/204340 | - |
dc.description.abstract | This study was designed to evaluate the additive effects of transforming growth factor-beta3 (TGF-beta 3) and hyaluronic acid (HA) on chondrogenic differentiation of human mesenchymal stem cells (hMSCs). The hMSCs were cultured on collagen type I-, HA-, or fibronectin-coated cell culture dishes with or without TGF-beta 3 added to the culture medium. Four weeks after cell culture, chondrogenic differentiation of hMSCs was determined by evaluating the expression of cartilage-specific markers using real-time polymerase chain reaction, immunocytochemistry, and Western blot analysis. hMSCs cultured on HA-coated dishes with TGF-beta 3 supplementation revealed a prominent increase in collagen type II, aggrecan, and Sox9. When hMSCs were cultured without TGF-beta 3 supplementation, only hMSCs cultured on HA-coated dishes showed prominent expression of the cartilage-specific markers. This study shows that chondrogenic differentiation of hMSCs can be enhanced additively by interactions with both a specific cell-adhesion matrix and a soluble growth factor. | - |
dc.language | 영어 | - |
dc.publisher | WILEY-BLACKWELL | - |
dc.title | Enhanced chondrogenic marker expression of human mesenchymal stem cells by interaction with both TGF-beta 3 and hyaluronic acid | - |
dc.title.alternative | Enhanced chondrogenic marker expression of human mesenchymal stem cells by interaction with both TGF-β3 and hyaluronic acid | - |
dc.type | Article | - |
dc.identifier.doi | 10.1002/bab.39 | - |
dc.citation.journaltitle | BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY | - |
dc.identifier.wosid | 000294583700009 | - |
dc.identifier.scopusid | 2-s2.0-80051779230 | - |
dc.citation.endpage | 276 | - |
dc.citation.number | 4 | - |
dc.citation.startpage | 271 | - |
dc.citation.volume | 58 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Kim, Byung-Soo | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | AUTOLOGOUS CHONDROCYTE TRANSPLANTATION | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | CARTILAGE | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | MATRIX | - |
dc.subject.keywordPlus | BONE | - |
dc.subject.keywordPlus | KNEE | - |
dc.subject.keywordPlus | DEDIFFERENTIATION | - |
dc.subject.keywordPlus | IMPLANTATION | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordAuthor | chondrogenesis | - |
dc.subject.keywordAuthor | human mesenchymal stem cells | - |
dc.subject.keywordAuthor | hyaluronic acid | - |
dc.subject.keywordAuthor | transforming growth factor-beta3 | - |
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