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Skin regeneration with fibroblast growth factor 2 released from heparin-conjugated fibrin

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dc.contributor.authorBhang, Suk Ho-
dc.contributor.authorSun, Ah-Young-
dc.contributor.authorYang, Hee Seok-
dc.contributor.authorRhim, Taiyoun-
dc.contributor.authorKim, Dong-Ik-
dc.contributor.authorKim, Byung-Soo-
dc.date.accessioned2024-06-13T02:18:10Z-
dc.date.available2024-06-13T02:18:10Z-
dc.date.created2018-06-19-
dc.date.created2018-06-19-
dc.date.issued2011-04-
dc.identifier.citationBIOTECHNOLOGY LETTERS, Vol.33 No.4, pp.845-851-
dc.identifier.issn0141-5492-
dc.identifier.urihttps://hdl.handle.net/10371/204345-
dc.description.abstractFibroblast growth factor 2 (FGF2) stimulates skin wound healing but does long-term delivery of FGF2 enhance skin regeneration compared to short-term delivery? Heparin-conjugated fibrin (HCF) was used as a vehicle for long-term delivery of FGF2. Fibrin, HCF, FGF2-loaded fibrin, and FGF2-loaded HCF were implanted into full-thickness skin defects of mice. The neoepidermis thickness was significantly larger in the FGF2-loaded HCF group than in the other groups, except for the FGF2-loaded fibrin group. Suprabasal cytokeratin differentiation in squamous neoepithelium was greatest in the FGF2-loaded HCF group. The enhanced skin regeneration accompanying the long-term delivery of FGF2 could be mediated, at least partially, by enhanced neovascularization and cell proliferation in the neodermis.-
dc.language영어-
dc.publisherSPRINGER-
dc.titleSkin regeneration with fibroblast growth factor 2 released from heparin-conjugated fibrin-
dc.typeArticle-
dc.identifier.doi10.1007/s10529-010-0492-5-
dc.citation.journaltitleBIOTECHNOLOGY LETTERS-
dc.identifier.wosid000288548900028-
dc.identifier.scopusid2-s2.0-79952743354-
dc.citation.endpage851-
dc.citation.number4-
dc.citation.startpage845-
dc.citation.volume33-
dc.description.isOpenAccessN-
dc.contributor.affiliatedAuthorKim, Byung-Soo-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.subject.keywordPlusENDOTHELIAL PROGENITOR CELLS-
dc.subject.keywordPlusWOUND REPAIR-
dc.subject.keywordPlusDIFFERENTIATION-
dc.subject.keywordPlusANGIOGENESIS-
dc.subject.keywordPlusPROLIFERATION-
dc.subject.keywordAuthorFibroblast growth factor 2-
dc.subject.keywordAuthorHeparin-conjugated fibrin-
dc.subject.keywordAuthorSkin regeneration-
dc.subject.keywordAuthorVascularization-
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  • College of Engineering
  • School of Chemical and Biological Engineering
Research Area biomaterials, nanomedicine, regenerative medicine

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