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Injectable hyaluronic acid-tyramine hydrogels for the treatment of rheumatoid arthritis
DC Field | Value | Language |
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dc.contributor.author | Kim, K. S. | - |
dc.contributor.author | Park, S. J. | - |
dc.contributor.author | Yang, J. -A. | - |
dc.contributor.author | Jeon, J. -H. | - |
dc.contributor.author | Bhang, S. H. | - |
dc.contributor.author | Kim, B. -S. | - |
dc.contributor.author | Hahn, S. K. | - |
dc.date.accessioned | 2024-06-13T02:18:20Z | - |
dc.date.available | 2024-06-13T02:18:20Z | - |
dc.date.created | 2018-06-19 | - |
dc.date.created | 2018-06-19 | - |
dc.date.issued | 2011-02 | - |
dc.identifier.citation | ACTA BIOMATERIALIA, Vol.7 No.2, pp.666-674 | - |
dc.identifier.issn | 1742-7061 | - |
dc.identifier.uri | https://hdl.handle.net/10371/204348 | - |
dc.description.abstract | Rheumatoid arthritis (RA) is a chronic inflammatory disease caused by inflammation of the synovial membrane, leading in turn to articular cartilage destruction. In this work, injectable tyramine modified hyaluronic acid (HA-Tyr) hydrogels were developed for the treatment of RA. HA-Tyr conjugate was synthesized by amide bond formation between carboxyl groups of HA and amine groups of tyramine. Then, HA-Tyr hydrogels were prepared by radical crosslinking reaction using H(2)O(2) and horse-radish peroxidase. Intra-articular injection of HA-Tyr hydrogels encapsulating dexamethasone (DMT) as a model drug resulted in successful treatment of RA with reduced interlukine-6, prostaglandin E2 and four types of cytokine levels in collagen-induced arthritis animal models. Histological analysis with hematoxylin and eosin (H&E) staining also confirmed the therapeutic effect of injectable HA-Tyr hydrogels with DMT. Taken together, the injectable HA-Tyr hydrogels were thought suitable to be developed as a therapeutically effective drug carrier for the treatment of RA. (C) 2010 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. | - |
dc.language | 영어 | - |
dc.publisher | ELSEVIER SCI LTD | - |
dc.title | Injectable hyaluronic acid-tyramine hydrogels for the treatment of rheumatoid arthritis | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.actbio.2010.09.030 | - |
dc.citation.journaltitle | ACTA BIOMATERIALIA | - |
dc.identifier.wosid | 000286707700022 | - |
dc.identifier.scopusid | 2-s2.0-78650742773 | - |
dc.citation.endpage | 674 | - |
dc.citation.number | 2 | - |
dc.citation.startpage | 666 | - |
dc.citation.volume | 7 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Kim, B. -S. | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | PROSTAGLANDIN-E SYNTHASE | - |
dc.subject.keywordPlus | INTRAARTICULAR INJECTION | - |
dc.subject.keywordPlus | TISSUE AUGMENTATION | - |
dc.subject.keywordPlus | CELL | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | OSTEOARTHRITIS | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | DESTRUCTION | - |
dc.subject.keywordPlus | DEGRADATION | - |
dc.subject.keywordAuthor | Hyaluronic acid | - |
dc.subject.keywordAuthor | Hydrogel | - |
dc.subject.keywordAuthor | Dexamethasone | - |
dc.subject.keywordAuthor | Drug delivery | - |
dc.subject.keywordAuthor | Rheumatoid arthritis | - |
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