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Injectable hyaluronic acid-tyramine hydrogels for the treatment of rheumatoid arthritis

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dc.contributor.authorKim, K. S.-
dc.contributor.authorPark, S. J.-
dc.contributor.authorYang, J. -A.-
dc.contributor.authorJeon, J. -H.-
dc.contributor.authorBhang, S. H.-
dc.contributor.authorKim, B. -S.-
dc.contributor.authorHahn, S. K.-
dc.date.accessioned2024-06-13T02:18:20Z-
dc.date.available2024-06-13T02:18:20Z-
dc.date.created2018-06-19-
dc.date.created2018-06-19-
dc.date.issued2011-02-
dc.identifier.citationACTA BIOMATERIALIA, Vol.7 No.2, pp.666-674-
dc.identifier.issn1742-7061-
dc.identifier.urihttps://hdl.handle.net/10371/204348-
dc.description.abstractRheumatoid arthritis (RA) is a chronic inflammatory disease caused by inflammation of the synovial membrane, leading in turn to articular cartilage destruction. In this work, injectable tyramine modified hyaluronic acid (HA-Tyr) hydrogels were developed for the treatment of RA. HA-Tyr conjugate was synthesized by amide bond formation between carboxyl groups of HA and amine groups of tyramine. Then, HA-Tyr hydrogels were prepared by radical crosslinking reaction using H(2)O(2) and horse-radish peroxidase. Intra-articular injection of HA-Tyr hydrogels encapsulating dexamethasone (DMT) as a model drug resulted in successful treatment of RA with reduced interlukine-6, prostaglandin E2 and four types of cytokine levels in collagen-induced arthritis animal models. Histological analysis with hematoxylin and eosin (H&E) staining also confirmed the therapeutic effect of injectable HA-Tyr hydrogels with DMT. Taken together, the injectable HA-Tyr hydrogels were thought suitable to be developed as a therapeutically effective drug carrier for the treatment of RA. (C) 2010 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.-
dc.language영어-
dc.publisherELSEVIER SCI LTD-
dc.titleInjectable hyaluronic acid-tyramine hydrogels for the treatment of rheumatoid arthritis-
dc.typeArticle-
dc.identifier.doi10.1016/j.actbio.2010.09.030-
dc.citation.journaltitleACTA BIOMATERIALIA-
dc.identifier.wosid000286707700022-
dc.identifier.scopusid2-s2.0-78650742773-
dc.citation.endpage674-
dc.citation.number2-
dc.citation.startpage666-
dc.citation.volume7-
dc.description.isOpenAccessN-
dc.contributor.affiliatedAuthorKim, B. -S.-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.subject.keywordPlusPROSTAGLANDIN-E SYNTHASE-
dc.subject.keywordPlusINTRAARTICULAR INJECTION-
dc.subject.keywordPlusTISSUE AUGMENTATION-
dc.subject.keywordPlusCELL-
dc.subject.keywordPlusTHERAPY-
dc.subject.keywordPlusOSTEOARTHRITIS-
dc.subject.keywordPlusPROLIFERATION-
dc.subject.keywordPlusINFLAMMATION-
dc.subject.keywordPlusDESTRUCTION-
dc.subject.keywordPlusDEGRADATION-
dc.subject.keywordAuthorHyaluronic acid-
dc.subject.keywordAuthorHydrogel-
dc.subject.keywordAuthorDexamethasone-
dc.subject.keywordAuthorDrug delivery-
dc.subject.keywordAuthorRheumatoid arthritis-
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  • College of Engineering
  • School of Chemical and Biological Engineering
Research Area biomaterials, nanomedicine, regenerative medicine

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