Publications
Detailed Information
Enhancement of in vivo bone regeneration efficacy of osteogenically undifferentiated human cord blood mesenchymal stem cells
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kang, Jin Muk | - |
dc.contributor.author | Kang, Sun‐Woong | - |
dc.contributor.author | La, Wan‐Geun | - |
dc.contributor.author | Yang, Yoon‐Sun | - |
dc.contributor.author | Kim, Byung‐Soo | - |
dc.date.accessioned | 2024-06-13T02:18:42Z | - |
dc.date.available | 2024-06-13T02:18:42Z | - |
dc.date.created | 2018-06-18 | - |
dc.date.created | 2018-06-18 | - |
dc.date.issued | 2010-05 | - |
dc.identifier.citation | JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, Vol.93A No.2, pp.666-672 | - |
dc.identifier.issn | 1549-3296 | - |
dc.identifier.uri | https://hdl.handle.net/10371/204355 | - |
dc.description.abstract | We hypothesized that bone morphogenetic protein-2 (BMP-2) would significantly enhance in vivo bone formation efficacy of osteogenically undifferentiated human cord blood mesenchymal stem cells (hCBMSCs). To test this hypothesis, poly(lactic-co-glycolic acid)/hydroxyapatite (PLGA/HA) scaffolds (group 1), BMP-2-loaded PLGA/HA scaffolds (group 2), undifferentiated hCBMSCs seeded on PLGA/HA scaffolds (group 3), undifferentiated hCBMSCs seeded on BMP-2-loaded PLGA/HA scaffolds (group 4), and osteogenically differentiated hCBMSCs seeded on PLGA/HA scaffolds (group 5) were implanted into dorsal, subcutaneous spaces of athymic mice for 8 weeks. Histological analysis showed that group 4 exhibited the largest bone formation area. RT-PCR analysis showed that human mRNA expression of osteoblastic markers such as ALP and osteocalcin in group 4 was higher than that of the other groups. Mouse osteoblastic markers of the host cells in the implants were also expressed more in group 4 than in the other groups. This study demonstrated that hCBMSCs that were not differentiated osteogenically in vitro prior to transplantation regenerate bone negligibly in vivo and that transplantation of osteogenically undifferentiated hCBMSCs with BMP-2 delivery results in much more extensive bone formation in vivo than that of undifferentiated or osteogenically differentiated hCBMSCs. © 2009 Wiley Periodicals, Inc. | - |
dc.language | 영어 | - |
dc.publisher | WILEY-BLACKWELL | - |
dc.title | Enhancement of in vivo bone regeneration efficacy of osteogenically undifferentiated human cord blood mesenchymal stem cells | - |
dc.type | Article | - |
dc.identifier.doi | 10.1002/jbm.a.32282 | - |
dc.citation.journaltitle | JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A | - |
dc.identifier.wosid | 000276351300027 | - |
dc.identifier.scopusid | 2-s2.0-77950278578 | - |
dc.citation.endpage | 672 | - |
dc.citation.number | 2 | - |
dc.citation.startpage | 666 | - |
dc.citation.volume | 93A | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Kim, Byung‐Soo | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | MORPHOGENETIC PROTEIN-2 | - |
dc.subject.keywordPlus | POROUS HYDROXYAPATITE | - |
dc.subject.keywordPlus | COMPOSITE SCAFFOLDS | - |
dc.subject.keywordPlus | PROGENITOR CELLS | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | MARROW | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | DEFECTS | - |
dc.subject.keywordPlus | VITRO | - |
dc.subject.keywordPlus | TRANSPLANTATION | - |
dc.subject.keywordAuthor | BMP-2 | - |
dc.subject.keywordAuthor | Bone regeneration | - |
dc.subject.keywordAuthor | Human cord blood mesenchymal stem cells | - |
dc.subject.keywordAuthor | Osteogenic differentiation | - |
dc.subject.keywordAuthor | Scaffold | - |
dc.subject.keywordAuthor | Tissue engineering | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.