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Cyclic mechanical strain promotes transforming-growth-factor-beta I-mediated cardiomyogenic marker expression in bone-marrow-derived mesenchymal stem cells in vitro : Cyclic mechanical strain promotes transforming-growth-factor-β1- mediated cardiomyogenic marker expression in bone-marrow-derived mesenchymal stem cells in vitro

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dc.contributor.authorBhang, Suk Ho-
dc.contributor.authorGwak, So-Jung-
dc.contributor.authorLee, Tae-Jin-
dc.contributor.authorKim, Sang-Soo-
dc.contributor.authorPark, Ho Hyun-
dc.contributor.authorPark, Moon Hyang-
dc.contributor.authorLee, Dae-Hee-
dc.contributor.authorLee, Soo-Hong-
dc.contributor.authorKim, Byung-Soo-
dc.date.accessioned2024-06-13T02:18:45Z-
dc.date.available2024-06-13T02:18:45Z-
dc.date.created2018-06-19-
dc.date.created2018-06-19-
dc.date.issued2010-04-
dc.identifier.citationBIOTECHNOLOGY AND APPLIED BIOCHEMISTRY, Vol.55 No.4, pp.191-197-
dc.identifier.issn0885-4513-
dc.identifier.urihttps://hdl.handle.net/10371/204356-
dc.description.abstractCardiomyocytes in the heart reside in mechanically dynamic environments, such as those subject to cyclic mechanical strain. TGF-beta I (transforming growth factor-beta I) stimulates cardiomyogenic marker expression of BMMSCs (bone-marrow-derived mesenchymal stem cells). In the present study, we tested the hypothesis that cyclic mechanical strain promotes TGF-beta I-mediated cardiomyogenic marker expression in BMMSCs in vitro. The mRNA expression of cardiac-specific genes was more up-regulated in BMMSCs cultured with a TGF-beta I supplement and subjected to cyclic strain for I week than in BMMSCs cultured statically with a TGF-beta I supplement. Immunocytochemical analyses and flow cytometric analysis showed that the proportions of cardiac troponin-I-positive cells and cardiac MHC (myosin heavy chain)-positive cells and the proportions of cells expressing tropomyosin respectively were increased to a greater extent by TGF-beta I with cyclic strain than by TGF-beta I alone. These results showed that cyclic strain promotes TGF-beta I mediated cardiomyogenic marker expression in BMMSCs in vitro.-
dc.language영어-
dc.publisherWILEY-
dc.titleCyclic mechanical strain promotes transforming-growth-factor-beta I-mediated cardiomyogenic marker expression in bone-marrow-derived mesenchymal stem cells in vitro-
dc.title.alternativeCyclic mechanical strain promotes transforming-growth-factor-β1- mediated cardiomyogenic marker expression in bone-marrow-derived mesenchymal stem cells in vitro-
dc.typeArticle-
dc.identifier.doi10.1042/BA20090307-
dc.citation.journaltitleBIOTECHNOLOGY AND APPLIED BIOCHEMISTRY-
dc.identifier.wosid000277984700003-
dc.identifier.scopusid2-s2.0-77954664294-
dc.citation.endpage197-
dc.citation.number4-
dc.citation.startpage191-
dc.citation.volume55-
dc.description.isOpenAccessN-
dc.contributor.affiliatedAuthorKim, Byung-Soo-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.subject.keywordPlusSMOOTH-MUSCLE CELLS-
dc.subject.keywordPlusSTROMAL CELLS-
dc.subject.keywordPlusMYOCARDIAL-INFARCTION-
dc.subject.keywordPlusDIFFERENTIATION-
dc.subject.keywordPlusTRANSPLANTATION-
dc.subject.keywordPlusCARDIOMYOCYTES-
dc.subject.keywordPlusTISSUE-
dc.subject.keywordPlusIMPLANTATION-
dc.subject.keywordPlusEFFICACY-
dc.subject.keywordPlusDELIVERY-
dc.subject.keywordAuthorbone-marrow-derived mesenchymal stem cell (BMMSC)-
dc.subject.keywordAuthorcardiomyogenic marker expression-
dc.subject.keywordAuthorcyclic mechanical strain-
dc.subject.keywordAuthortransforming growth factor-beta I (TGF-beta I)-
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  • School of Chemical and Biological Engineering
Research Area biomaterials, nanomedicine, regenerative medicine

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