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Enhanced bone formation by marrow-derived endothelial and osteogenic cell transplantation
Cited 12 time in
Web of Science
Cited 13 time in Scopus
- Authors
- Issue Date
- 2010-01
- Publisher
- John Wiley & Sons Inc.
- Citation
- Journal of Biomedical Materials Research - Part A, Vol.92A No.1, pp.246-253
- Abstract
- Bone marrow-derived osteogenic cells can regenerate bone tissues in vivo. The aim of the present study is to determine whether the cotransplantation of bone marrow-derived endothelial-like cells (BMECs) enhances bone regeneration by bone marrow-derived osteogenic cell (BMOC) transplantation in osseous defects. Canine bone marrow cells were differentiated separately into BMECs and BMOCs. Using apatite-coated poly(lactide-co-glycolide)/hydroxyapatite composite scaffolds as cell delivery vehicles, BMOCs were transplanted with or without BMECs into critical-sized calvarial defects in immunodeficient mice. Histological analyses, microcomputed tomography, and soft X-ray were performed to assess mineralized bone formation at 8 weeks. Cotransplantation of BMECs and BMOCs resulted in greater bone formation than transplantation of BMOCs alone. There was a significant (p < 0.05) increase in bone formation area following cotransplantation (30.8% +/- 2.5%), compared with transplantation of BMOCs alone (15.3% +/- 1.9%). These results demonstrate that the cotransplantation of BMECs enhances bone regeneration mediated by BMOC transplantation in osseous defects. (C) 2009 Wiley Periodicals, Inc. J Biomed Mater Res 92A: 246-253, 2010
- ISSN
- 1549-3296
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