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Solid Free-Form Fabrication-Based PCL/HA Scaffolds Fabricated with a Multi-head Deposition System for Bone Tissue Engineering

DC Field Value Language
dc.contributor.authorKim, Jong Young-
dc.contributor.authorLee, Tae-Jin-
dc.contributor.authorCho, Dong-Woo-
dc.contributor.authorKim, Byung-Soo-
dc.date.accessioned2024-06-13T02:19:00Z-
dc.date.available2024-06-13T02:19:00Z-
dc.date.created2018-06-19-
dc.date.created2018-06-19-
dc.date.issued2010-
dc.identifier.citationJournal of Biomaterials Science, Polymer Edition, Vol.21 No.6-7, pp.951-962-
dc.identifier.issn0920-5063-
dc.identifier.urihttps://hdl.handle.net/10371/204361-
dc.description.abstractIn this study, we fabricated polycaprolactone/hydroxyapatite (PCL/HA) scaffolds with a multi-head deposition system, a solid free-form fabrication technology that was developed in our previous study. The bone regeneration potential of the scaffolds was compared with that of PCL scaffolds fabricated with the same system. The fabricated scaffolds had a pore size of 400 mu m and a porosity of 66.7%. The PCL/HA scaffolds had higher mechanical strength and modulus than the PCL scaffolds. To compare the osteogenic potential, the two types of scaffolds were seeded with rat osteoblasts and cultured in vitro or implanted subcutaneously into athymic mice. The cells cultured on PCL/HA scaffolds expressed higher levels of osteopontin and osteonectin, both of which are osteogenic proteins. The PCL/HA scaffolds resulted in larger bone area and calcium deposition in the implants compared to the PCL scaffolds. (C) Koninklijke Brill NV, Leiden, 2010-
dc.language영어-
dc.publisherTaylor & Francis-
dc.titleSolid Free-Form Fabrication-Based PCL/HA Scaffolds Fabricated with a Multi-head Deposition System for Bone Tissue Engineering-
dc.typeArticle-
dc.identifier.doi10.1163/156856209X458380-
dc.citation.journaltitleJournal of Biomaterials Science, Polymer Edition-
dc.identifier.wosid000278015500018-
dc.identifier.scopusid2-s2.0-77952196217-
dc.citation.endpage962-
dc.citation.number6-7-
dc.citation.startpage951-
dc.citation.volume21-
dc.description.isOpenAccessN-
dc.contributor.affiliatedAuthorKim, Byung-Soo-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.subject.keywordPlusCOMPOSITE SCAFFOLDS-
dc.subject.keywordPlusSTROMAL CELLS-
dc.subject.keywordPlusIN-VITRO-
dc.subject.keywordPlusDESIGN-
dc.subject.keywordPlusPOLYCAPROLACTONE-
dc.subject.keywordPlusPHOSPHATE-
dc.subject.keywordPlusOSTEOGENESIS-
dc.subject.keywordAuthorBone regeneration-
dc.subject.keywordAuthorPCL/HA scaffold-
dc.subject.keywordAuthormulti-head deposition system-
dc.subject.keywordAuthorsolid free-form fabrication-
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  • College of Engineering
  • School of Chemical and Biological Engineering
Research Area biomaterials, nanomedicine, regenerative medicine

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