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Apatite-Coated Porous Poly(lactic-co-glycolic acid) Microspheres as an Injectable Bone Substitute
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Tae-Jin | - |
dc.contributor.author | Kang, Sun-Woong | - |
dc.contributor.author | Bhang, Suk Ho | - |
dc.contributor.author | Kang, Jin Muk | - |
dc.contributor.author | Kim, Byung-Soo | - |
dc.date.accessioned | 2024-06-13T02:19:03Z | - |
dc.date.available | 2024-06-13T02:19:03Z | - |
dc.date.created | 2018-06-19 | - |
dc.date.created | 2018-06-19 | - |
dc.date.issued | 2010 | - |
dc.identifier.citation | JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION, Vol.21 No.5, pp.635-645 | - |
dc.identifier.issn | 0920-5063 | - |
dc.identifier.uri | https://hdl.handle.net/10371/204362 | - |
dc.description.abstract | Previously, we developed an apatite-coated non-porous poly(lactic-co-glycolic acid) (PLGA) microsphere (ANPM) as an injectable bone substitute. We hypothesized that an apatite-coated porous PLGA microsphere (APPM) would have enhanced osteogenic potential compared to that of an ANPM. To test the hypothesis, critical-sized bone defects were made in mouse calvaria, and APPMs and ANPMs were implanted in the defects for 8 weeks. New bone formed around both types of bone substitutes implanted in mouse calvarial defects. Importantly, the portion of bone-like tissue area in the implant cross-sectional area was significantly higher in the APPM group than in the ANPM group (36.9% versus 14.6%, P < 0.001). Fluorochrome-labeling analysis showed that bone regeneration occurred in the pores of implanted APPMs. The results show that APPM may be useful as a bone substitute in orthopedic applications. (C) Koninklijke Brill NV, Leiden, 2010 | - |
dc.language | 영어 | - |
dc.publisher | TAYLOR & FRANCIS LTD | - |
dc.title | Apatite-Coated Porous Poly(lactic-co-glycolic acid) Microspheres as an Injectable Bone Substitute | - |
dc.type | Article | - |
dc.identifier.doi | 10.1163/156856209X434656 | - |
dc.citation.journaltitle | JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION | - |
dc.identifier.wosid | 000275981700007 | - |
dc.identifier.scopusid | 2-s2.0-77950216927 | - |
dc.citation.endpage | 645 | - |
dc.citation.number | 5 | - |
dc.citation.startpage | 635 | - |
dc.citation.volume | 21 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Kim, Byung-Soo | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | COMPOSITE SCAFFOLDS | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | HYDROXYAPATITE | - |
dc.subject.keywordAuthor | Apatite-coated porous PLGA microspheres | - |
dc.subject.keywordAuthor | bone regeneration | - |
dc.subject.keywordAuthor | biodegradable polymer | - |
dc.subject.keywordAuthor | poly(lactic-co-glycolic acid) microsphere | - |
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