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Apatite-Coated Porous Poly(lactic-co-glycolic acid) Microspheres as an Injectable Bone Substitute

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dc.contributor.authorLee, Tae-Jin-
dc.contributor.authorKang, Sun-Woong-
dc.contributor.authorBhang, Suk Ho-
dc.contributor.authorKang, Jin Muk-
dc.contributor.authorKim, Byung-Soo-
dc.date.accessioned2024-06-13T02:19:03Z-
dc.date.available2024-06-13T02:19:03Z-
dc.date.created2018-06-19-
dc.date.created2018-06-19-
dc.date.issued2010-
dc.identifier.citationJOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION, Vol.21 No.5, pp.635-645-
dc.identifier.issn0920-5063-
dc.identifier.urihttps://hdl.handle.net/10371/204362-
dc.description.abstractPreviously, we developed an apatite-coated non-porous poly(lactic-co-glycolic acid) (PLGA) microsphere (ANPM) as an injectable bone substitute. We hypothesized that an apatite-coated porous PLGA microsphere (APPM) would have enhanced osteogenic potential compared to that of an ANPM. To test the hypothesis, critical-sized bone defects were made in mouse calvaria, and APPMs and ANPMs were implanted in the defects for 8 weeks. New bone formed around both types of bone substitutes implanted in mouse calvarial defects. Importantly, the portion of bone-like tissue area in the implant cross-sectional area was significantly higher in the APPM group than in the ANPM group (36.9% versus 14.6%, P < 0.001). Fluorochrome-labeling analysis showed that bone regeneration occurred in the pores of implanted APPMs. The results show that APPM may be useful as a bone substitute in orthopedic applications. (C) Koninklijke Brill NV, Leiden, 2010-
dc.language영어-
dc.publisherTAYLOR & FRANCIS LTD-
dc.titleApatite-Coated Porous Poly(lactic-co-glycolic acid) Microspheres as an Injectable Bone Substitute-
dc.typeArticle-
dc.identifier.doi10.1163/156856209X434656-
dc.citation.journaltitleJOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION-
dc.identifier.wosid000275981700007-
dc.identifier.scopusid2-s2.0-77950216927-
dc.citation.endpage645-
dc.citation.number5-
dc.citation.startpage635-
dc.citation.volume21-
dc.description.isOpenAccessN-
dc.contributor.affiliatedAuthorKim, Byung-Soo-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.subject.keywordPlusCOMPOSITE SCAFFOLDS-
dc.subject.keywordPlusIN-VITRO-
dc.subject.keywordPlusHYDROXYAPATITE-
dc.subject.keywordAuthorApatite-coated porous PLGA microspheres-
dc.subject.keywordAuthorbone regeneration-
dc.subject.keywordAuthorbiodegradable polymer-
dc.subject.keywordAuthorpoly(lactic-co-glycolic acid) microsphere-
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  • College of Engineering
  • School of Chemical and Biological Engineering
Research Area biomaterials, nanomedicine, regenerative medicine

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