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Mechanical properties and degradation behaviors of hyaluronic acid hydrogels cross-linked at various cross-linking densities
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jeon, Oju | - |
dc.contributor.author | Song, Su Jin | - |
dc.contributor.author | Lee, Kee-Jung | - |
dc.contributor.author | Park, Moon Hyang | - |
dc.contributor.author | Lee, Soo-Hong | - |
dc.contributor.author | Hahn, Sei Kwang | - |
dc.contributor.author | Kim, Sungjee | - |
dc.contributor.author | Kim, Byung-Soo | - |
dc.date.accessioned | 2024-06-13T02:20:00Z | - |
dc.date.available | 2024-06-13T02:20:00Z | - |
dc.date.created | 2018-06-18 | - |
dc.date.created | 2018-06-18 | - |
dc.date.issued | 2007-10 | - |
dc.identifier.citation | Carbohydrate Polymers, Vol.70 No.3, pp.251-257 | - |
dc.identifier.issn | 0144-8617 | - |
dc.identifier.uri | https://hdl.handle.net/10371/204380 | - |
dc.description.abstract | The effect of cross-linking density of hyaluronic acid (HA) hydrogels on mechanical properties and degradation behaviors has been investigated. HA hydrogels were prepared by the covalent cross-linking of HA with poly(ethylene glycol)-diamine with two different molecular weights at various cross-linking densities. The elastic modulus increased gradually as the theoretical cross-linking density of HA hydrogels increased from 0% to 20%. However, as the theoretical cross-linking density increased above 20%, the elastic modulus decreased. At a theoretical cross-linking density of 20%, the elastic modulus increased as the molecular weight of the cross-linking molecule decreased. In vitro degradation rates of HA hydrogels decreased as the molecular weight of the cross-linking molecule decreased at a theoretical cross-linking density of 20%. The degradation rate of the cross-linked HA hydrogels decreased with increases in the theoretical cross-linking density from 0% to 20%. However, there was no significant difference in the degradation rate as the theoretical cross-linking density increased above 30%. With controllable mechanical properties and degradation rates, the developed HA hydrogels would be further investigated for various medical applications. (c) 2007 Elsevier Ltd. All rights reserved. | - |
dc.language | 영어 | - |
dc.publisher | Pergamon Press Ltd. | - |
dc.title | Mechanical properties and degradation behaviors of hyaluronic acid hydrogels cross-linked at various cross-linking densities | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.carbpol.2007.04.002 | - |
dc.citation.journaltitle | Carbohydrate Polymers | - |
dc.identifier.wosid | 000250257600001 | - |
dc.identifier.scopusid | 2-s2.0-34548502425 | - |
dc.citation.endpage | 257 | - |
dc.citation.number | 3 | - |
dc.citation.startpage | 251 | - |
dc.citation.volume | 70 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Kim, Byung-Soo | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | FIBROBLAST-GROWTH-FACTOR | - |
dc.subject.keywordPlus | FUNCTIONALIZED DERIVATIVES | - |
dc.subject.keywordPlus | FIBRIN MATRIX | - |
dc.subject.keywordPlus | TRANSPLANTATION | - |
dc.subject.keywordPlus | BIOMATERIALS | - |
dc.subject.keywordPlus | RIGIDITY | - |
dc.subject.keywordPlus | ALGINATE | - |
dc.subject.keywordPlus | RELEASE | - |
dc.subject.keywordPlus | FILMS | - |
dc.subject.keywordAuthor | cross-linking | - |
dc.subject.keywordAuthor | degradation | - |
dc.subject.keywordAuthor | elastic modulus | - |
dc.subject.keywordAuthor | hyaluronic acid | - |
dc.subject.keywordAuthor | hydrogel | - |
dc.subject.keywordAuthor | poly(ethylene glycol) | - |
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