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Enhancement of ectopic bone formation by bone morphogenetic protein-2 released from a heparin-conjugated poly(L-lactic-co-glycolic acid) scaffold
DC Field | Value | Language |
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dc.contributor.author | Jeon, Oju | - |
dc.contributor.author | Song, Su Jin | - |
dc.contributor.author | Kang, Sun-Woong | - |
dc.contributor.author | Putnam, Andrew J. | - |
dc.contributor.author | Kim, Byung-Soo | - |
dc.date.accessioned | 2024-06-13T02:20:16Z | - |
dc.date.available | 2024-06-13T02:20:16Z | - |
dc.date.created | 2018-06-18 | - |
dc.date.created | 2018-06-18 | - |
dc.date.issued | 2007-06 | - |
dc.identifier.citation | BIOMATERIALS, Vol.28 No.17, pp.2763-2771 | - |
dc.identifier.issn | 0142-9612 | - |
dc.identifier.uri | https://hdl.handle.net/10371/204385 | - |
dc.description.abstract | In this study, a heparin-conjugated poly(L-lactic-co-glycolic acid) (HP-PLGA) scaffold was developed for the sustained delivery of bone morphogenetic protein-2 (BMP-2), and then used to address the hypothesis that BMP-2 delivered from this scaffold could enhance ectopic bone formation. We found the amount of heparin conjugated to the PLGA scaffolds could be increased up to 3.2-fold by using scaffolds made from star-shaped PLGA, as compared to scaffolds made from linear PLGA, and that the release of BMP-2 from the HP-PLGA scaffold was sustained for at least 14 days in vitro. The BMP-2 released from the HP-PLGA scaffold stimulated an increase in alkaline phosphatase (ALP) activity of osteoblasts for 14 days in vitro, suggesting that the HP-PLGA scaffold delivery system releases BMP-2 in a bioactive form for a prolonged period. By contrast, BMP-2 release from unmodified (no heparin) PLGA scaffolds induced a transient increase in ALP activity for the first 3 days and a decrease thereafter. In vivo bone formation studies showed the BMP-2-loaded HP-PLGA scaffolds induced bone formation to a much greater extent than did either BMP-2-loaded unmodified PLGA scaffolds or unloaded (no BMP-2) HP-PLGA scaffolds, with 9-fold greater bone formation area and 4-fold greater calcium content in the BMP-2-loaded HP-PLGA scaffold group compared to the BMP-2-loaded unmodified PLGA scaffold group. Collectively, these results demonstrate that the HP-PLGA delivery system is capable of potentiating the osteogenic efficacy of BMP-2, and underscore its importance as a possible bone regeneration strategy. (c) 2007 Elsevier Ltd. All rights reserved. | - |
dc.language | 영어 | - |
dc.publisher | ELSEVIER SCI LTD | - |
dc.title | Enhancement of ectopic bone formation by bone morphogenetic protein-2 released from a heparin-conjugated poly(L-lactic-co-glycolic acid) scaffold | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.biomaterials.2007.02.023 | - |
dc.citation.journaltitle | BIOMATERIALS | - |
dc.identifier.wosid | 000246097300008 | - |
dc.identifier.scopusid | 2-s2.0-33947178806 | - |
dc.citation.endpage | 2771 | - |
dc.citation.number | 17 | - |
dc.citation.startpage | 2763 | - |
dc.citation.volume | 28 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Kim, Byung-Soo | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | FIBROBLAST-GROWTH-FACTOR | - |
dc.subject.keywordPlus | FIBRIN GEL | - |
dc.subject.keywordPlus | FUSION | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordPlus | COLLAGEN | - |
dc.subject.keywordPlus | MATRIX | - |
dc.subject.keywordAuthor | bone morphogenetic protein | - |
dc.subject.keywordAuthor | bone regeneration | - |
dc.subject.keywordAuthor | poly(L-lactide-co-glycolide) | - |
dc.subject.keywordAuthor | scaffold | - |
dc.subject.keywordAuthor | sustained delivery | - |
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