Publications

Detailed Information

Tissue engineering of heart valves in vivo using bone marrow-derived cells

Cited 23 time in Web of Science Cited 30 time in Scopus
Authors

Kim, SS; Lim, SH; Hong, YS; Cho, SW; Ryu, JH; Chang, BC; Choi, CY; Kim, BS

Issue Date
2006-07
Publisher
Blackwell Publishing Inc.
Citation
Artificial Organs, Vol.30 No.7, pp.554-557
Abstract
In this study, we tissue-engineered heart valves in vivo using autologous bone marrow-derived cells (BMCs). Canine BMCs were differentiated into endothelial cell (EC)-like cells and myofibroblast (MF)-like cells. Decellularized porcine pulmonary valves were seeded with BMCs and implanted to abdominal aorta and pulmonary valve of bone marrow donor dogs. Histological examination of the explants identified the regeneration of valvular structures expressing CD31 and smooth muscle alpha-actin, indicating the presence of EC-like and MF-like cells in the grafts at 3 and 1 week, respectively, after implantation. Fluorescent microscopic examinations identified the presence of fluorescently labeled cells in the explants, indicating that the implanted BMCs survived and participated in the heart valve reconstitution. This study reports, for the first time, on tissue engineering of heart valve in vivo using BMCs.
ISSN
0160-564X
URI
https://hdl.handle.net/10371/204406
DOI
https://doi.org/10.1111/j.1525-1594.2006.00258.x
Files in This Item:
There are no files associated with this item.
Appears in Collections:

Related Researcher

  • College of Engineering
  • School of Chemical and Biological Engineering
Research Area biomaterials, nanomedicine, regenerative medicine

Altmetrics

Item View & Download Count

  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Share