Publications
Detailed Information
배아줄기세포 이식과 사이토카인 투여의 복합치료술을 적용한 심근경색 치료 : Combined therapy using embryonic stem cell transplantation and cytokine administration for treatment of myocardial infarction
Cited 0 time in
Web of Science
Cited 0 time in Scopus
- Authors
- Issue Date
- 2006-03
- Publisher
- 한국조직공학과 재생의학회
- Citation
- 조직공학과 재생의학, Vol.3 No.1, pp.52-57
- Abstract
- In the present study, we tested the hypothesis that granulocyte colony-stimulating factor (G-CSF) administration would enhance the efficacy of cellular cardiomyoplasty with embryonic stem (ES) cells in infarcted myocardium. Three weeks after myocardial infarction by cryoinjury, Sprague-Dawley rats were randomized to receive either an injection of medium, ES cell transplantation, G-CSF administration, or a combination of G-CSF administration and ES cell transplantation. Prior to transplantation, ES cells were induced to differentiate into cardiomyocytes. Eight weeks after treatment, the cardiac tissue formation, neovascularization, and apoptotic activity in the infarct regions were evaluated by histology and immunohistochemistry. The left ventricular (LV) dimensions and function of the treated heart were evaluated by echocardiography. Transplanted ES cells survived and participated in the myocardial regeneration in the infarcted heart. A combination of G-CSF treatment and ES cell transplantation significantly promoted angiogenesis and reduced the infarct area and cell apoptosis in the infarcted myocardium compared with ES cell transplantation alone. The combination therapy also attenuated LV dilation, ascompared with ES cell transplantation alone. The present study demonstrates that G-CSF treatment can enhance the efficacy of cellular cardiomyoplasty by ES cell transplantation to treat myocardial infarction.
- ISSN
- 1738-2696
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.