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Granulocyte colony-stimulating factor treatment enhances the efficacy of cellular cardiomyoplasty with transplantation of embryonic stem cell-derived cardiomyocytes in infarcted myocardium

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dc.contributor.authorCho, Seung-Woo-
dc.contributor.authorGwak, So-Jung-
dc.contributor.authorKim, Il-Kwon-
dc.contributor.authorCho, Myeong-Chan-
dc.contributor.authorHwang, Kyung-Kuk-
dc.contributor.authorKwon, Jin-Sook-
dc.contributor.authorChoi, Cha Yong-
dc.contributor.authorYoo, Kyung Jong-
dc.contributor.authorKim, Byung-Soo-
dc.date.accessioned2024-06-13T02:22:04Z-
dc.date.available2024-06-13T02:22:04Z-
dc.date.created2018-06-20-
dc.date.created2018-06-20-
dc.date.issued2006-02-
dc.identifier.citationBiochemical and Biophysical Research Communications, Vol.340 No.2, pp.573-582-
dc.identifier.issn0006-291X-
dc.identifier.urihttps://hdl.handle.net/10371/204419-
dc.description.abstractWe tested the hypothesis that granulocyte colony-stimulating factor (G-CSF) administration would enhance the efficacy of cellular cardiomyoplasty with embryonic stem (ES) cell-derived cardiomyocytes in infarcted myocardium. Three weeks after myocardial infraction by cryoinjury, Sprague-Dawley rats were randomized to receive either an injection of medium, ES cell-derived cardiomyocyte transplantation, G-CSF administration, or a combination of G-CSF administration and ES cell-derived cardiomyocyte transplantation. Eight weeks after treatment, the cardiac tissue formation, neovascularization. and apoptotic activity in the infarct regions were evaluated by histology and immunohistochemistry. The left ventricular (LV) dimensions and function of the treated heart were evaluated by echocardiography. Transplanted ES cell-derived cardiomyocytes survived and participated in the myocardial regeneration in the infarcted heart. A combination of G-CSF treatment and ES cell-derived cardiomyocyte transplantation significantly promoted angiogenesis and reduced the infarct area and cell apoptosis in the infarcted myocardium compared with ES cell-derived cardiomyocyte transplantation alone. The combination therapy also attenuated LV dilation, as compared with ES cell-derived cardiomyocyte transplantation alone. G-CSF treatment can enhance the efficacy of cellular cardiomyoplasty by ES cell-derived cardiomyocyte transplantation to treat myocardial infarction. (c) 2005 Elsevier Inc. All rights reserved.-
dc.language영어-
dc.publisherAcademic Press-
dc.titleGranulocyte colony-stimulating factor treatment enhances the efficacy of cellular cardiomyoplasty with transplantation of embryonic stem cell-derived cardiomyocytes in infarcted myocardium-
dc.typeArticle-
dc.identifier.doi10.1016/j.bbrc.2005.12.044-
dc.citation.journaltitleBiochemical and Biophysical Research Communications-
dc.identifier.wosid000234731800032-
dc.identifier.scopusid2-s2.0-29644438615-
dc.citation.endpage582-
dc.citation.number2-
dc.citation.startpage573-
dc.citation.volume340-
dc.description.isOpenAccessN-
dc.contributor.affiliatedAuthorChoi, Cha Yong-
dc.contributor.affiliatedAuthorKim, Byung-Soo-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.subject.keywordPlusBONE-MARROW-CELLS-
dc.subject.keywordPlusG-CSF-
dc.subject.keywordPlusIN-VITRO-
dc.subject.keywordPlusCARDIAC-FUNCTION-
dc.subject.keywordPlusDIFFERENTIATE-
dc.subject.keywordPlusHEART-
dc.subject.keywordPlusNEOVASCULARIZATION-
dc.subject.keywordPlusIMPLANTATION-
dc.subject.keywordPlusIMPROVES-
dc.subject.keywordPlusREPAIR-
dc.subject.keywordAuthorembryonic stem cell-derived cardiomyocyte-
dc.subject.keywordAuthorgranulocyte colony-stimulating factor-
dc.subject.keywordAuthormyocardial infarction-
dc.subject.keywordAuthorneovascularization-
dc.subject.keywordAuthormyocardial regeneration-
dc.subject.keywordAuthorcellular cardiomyoplasty-
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Research Area biomaterials, nanomedicine, regenerative medicine

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