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Enhancement of in vivo endothelialization of tissue-engineered vascular grafts by granulocyte colony-stimulating factor
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Seung‐Woo Cho | - |
dc.contributor.author | Joung Eun Lim | - |
dc.contributor.author | Hun Su Chu | - |
dc.contributor.author | Hye‐Jin Hyun | - |
dc.contributor.author | Cha Yong Choi | - |
dc.contributor.author | Ki‐Chul Hwang | - |
dc.contributor.author | Kyung Jong Yoo | - |
dc.contributor.author | Dong‐Ik Kim | - |
dc.contributor.author | Byung‐Soo Kim | - |
dc.date.accessioned | 2024-06-13T02:22:19Z | - |
dc.date.available | 2024-06-13T02:22:19Z | - |
dc.date.created | 2018-06-20 | - |
dc.date.created | 2018-06-20 | - |
dc.date.issued | 2006-02 | - |
dc.identifier.citation | Journal of Biomedical Materials Research - Part A, Vol.76A No.2, pp.252-263 | - |
dc.identifier.issn | 1549-3296 | - |
dc.identifier.uri | https://hdl.handle.net/10371/204420 | - |
dc.description.abstract | Successful reconstruction of large-diameter blood vessel in humans has been demonstrated using the tissue engineering technique, but improvement in patency of small-diameter bioartificial vascular graft remains a great challenge. This study reports that granulocyte colony-stimulating factor (G-CSF) can enhance in vivo endothelialization of tissue-engineered vascular grafts, which could be used to improve patency of small-diameter vascular graft. Vascular grafts were tissue engineered with decellularized canine abdominal aortas and canine autologous bone marrow-derived cells. Prior to cell seeding onto decellularized graft matrices, bone marrow-derived cells were induced to differentiate into endothelial cells and smooth muscle cells. The cell-seeded vascular grafts were implanted into the abdominal aortas of bone marrow donor dogs. Before and after graft implantation, G-CSF was administered subcutaneously to the dogs (n = 3). The grafts implanted into the dogs not receiving G-CSF were used as controls (n = 3). Eight weeks after implantation, grafts in both groups showed regeneration of vascular tissues including endotheliurn and smooth muscle. Importantly, endothelium formation was more extensive in the G-CSF-treated grafts than in the control grafts, as assessed with reverse transcription polymerase chain reaction, western blot, and immunohistochemistry. In addition, intimal hyperplasia was significantly reduced in the G-CSF-treated grafts compared to the control grafts. This study suggests that G-CSF administration could be applied to improve patency of small-diameter tissue-engineered vascular grafts. (c) 2005 Wiley Periodicals, Inc. | - |
dc.language | 영어 | - |
dc.publisher | John Wiley & Sons Inc. | - |
dc.title | Enhancement of in vivo endothelialization of tissue-engineered vascular grafts by granulocyte colony-stimulating factor | - |
dc.type | Article | - |
dc.identifier.doi | 10.1002/jbm.a.30535 | - |
dc.citation.journaltitle | Journal of Biomedical Materials Research - Part A | - |
dc.identifier.wosid | 000234545600004 | - |
dc.identifier.scopusid | 2-s2.0-33645108250 | - |
dc.citation.endpage | 263 | - |
dc.citation.number | 2 | - |
dc.citation.startpage | 252 | - |
dc.citation.volume | 76A | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Cha Yong Choi | - |
dc.contributor.affiliatedAuthor | Byung‐Soo Kim | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | CYTOKINE-INDUCED MOBILIZATION | - |
dc.subject.keywordPlus | MUSCLE-CELL-PROLIFERATION | - |
dc.subject.keywordPlus | MARROW-DERIVED CELLS | - |
dc.subject.keywordPlus | PROGENITOR CELLS | - |
dc.subject.keywordPlus | THERAPEUTIC ANGIOGENESIS | - |
dc.subject.keywordPlus | VITRO | - |
dc.subject.keywordPlus | TRANSPLANTATION | - |
dc.subject.keywordPlus | REGENERATION | - |
dc.subject.keywordPlus | AUTOGRAFTS | - |
dc.subject.keywordPlus | PROSTHESES | - |
dc.subject.keywordAuthor | tissue-engineered vascular graft | - |
dc.subject.keywordAuthor | bone marrow-derived cell | - |
dc.subject.keywordAuthor | decellularized tissue matrix | - |
dc.subject.keywordAuthor | granulocyte colony-stimulating factor | - |
dc.subject.keywordAuthor | endothelialization | - |
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