Publications

Detailed Information

Enhancement of in vivo endothelialization of tissue-engineered vascular grafts by granulocyte colony-stimulating factor

DC Field Value Language
dc.contributor.authorSeung‐Woo Cho-
dc.contributor.authorJoung Eun Lim-
dc.contributor.authorHun Su Chu-
dc.contributor.authorHye‐Jin Hyun-
dc.contributor.authorCha Yong Choi-
dc.contributor.authorKi‐Chul Hwang-
dc.contributor.authorKyung Jong Yoo-
dc.contributor.authorDong‐Ik Kim-
dc.contributor.authorByung‐Soo Kim-
dc.date.accessioned2024-06-13T02:22:19Z-
dc.date.available2024-06-13T02:22:19Z-
dc.date.created2018-06-20-
dc.date.created2018-06-20-
dc.date.issued2006-02-
dc.identifier.citationJournal of Biomedical Materials Research - Part A, Vol.76A No.2, pp.252-263-
dc.identifier.issn1549-3296-
dc.identifier.urihttps://hdl.handle.net/10371/204420-
dc.description.abstractSuccessful reconstruction of large-diameter blood vessel in humans has been demonstrated using the tissue engineering technique, but improvement in patency of small-diameter bioartificial vascular graft remains a great challenge. This study reports that granulocyte colony-stimulating factor (G-CSF) can enhance in vivo endothelialization of tissue-engineered vascular grafts, which could be used to improve patency of small-diameter vascular graft. Vascular grafts were tissue engineered with decellularized canine abdominal aortas and canine autologous bone marrow-derived cells. Prior to cell seeding onto decellularized graft matrices, bone marrow-derived cells were induced to differentiate into endothelial cells and smooth muscle cells. The cell-seeded vascular grafts were implanted into the abdominal aortas of bone marrow donor dogs. Before and after graft implantation, G-CSF was administered subcutaneously to the dogs (n = 3). The grafts implanted into the dogs not receiving G-CSF were used as controls (n = 3). Eight weeks after implantation, grafts in both groups showed regeneration of vascular tissues including endotheliurn and smooth muscle. Importantly, endothelium formation was more extensive in the G-CSF-treated grafts than in the control grafts, as assessed with reverse transcription polymerase chain reaction, western blot, and immunohistochemistry. In addition, intimal hyperplasia was significantly reduced in the G-CSF-treated grafts compared to the control grafts. This study suggests that G-CSF administration could be applied to improve patency of small-diameter tissue-engineered vascular grafts. (c) 2005 Wiley Periodicals, Inc.-
dc.language영어-
dc.publisherJohn Wiley & Sons Inc.-
dc.titleEnhancement of in vivo endothelialization of tissue-engineered vascular grafts by granulocyte colony-stimulating factor-
dc.typeArticle-
dc.identifier.doi10.1002/jbm.a.30535-
dc.citation.journaltitleJournal of Biomedical Materials Research - Part A-
dc.identifier.wosid000234545600004-
dc.identifier.scopusid2-s2.0-33645108250-
dc.citation.endpage263-
dc.citation.number2-
dc.citation.startpage252-
dc.citation.volume76A-
dc.description.isOpenAccessN-
dc.contributor.affiliatedAuthorCha Yong Choi-
dc.contributor.affiliatedAuthorByung‐Soo Kim-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.subject.keywordPlusCYTOKINE-INDUCED MOBILIZATION-
dc.subject.keywordPlusMUSCLE-CELL-PROLIFERATION-
dc.subject.keywordPlusMARROW-DERIVED CELLS-
dc.subject.keywordPlusPROGENITOR CELLS-
dc.subject.keywordPlusTHERAPEUTIC ANGIOGENESIS-
dc.subject.keywordPlusVITRO-
dc.subject.keywordPlusTRANSPLANTATION-
dc.subject.keywordPlusREGENERATION-
dc.subject.keywordPlusAUTOGRAFTS-
dc.subject.keywordPlusPROSTHESES-
dc.subject.keywordAuthortissue-engineered vascular graft-
dc.subject.keywordAuthorbone marrow-derived cell-
dc.subject.keywordAuthordecellularized tissue matrix-
dc.subject.keywordAuthorgranulocyte colony-stimulating factor-
dc.subject.keywordAuthorendothelialization-
Appears in Collections:
Files in This Item:
There are no files associated with this item.

Related Researcher

  • College of Engineering
  • School of Chemical and Biological Engineering
Research Area biomaterials, nanomedicine, regenerative medicine

Altmetrics

Item View & Download Count

  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Share