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Tissue engineering of cartilage with chondrocytes cultured in a chemically-defined, serum-free medium

Cited 13 time in Web of Science Cited 13 time in Scopus
Authors

Byung-Soo Kim; Sung Pil Yoo; Hong-Woo Park

Issue Date
2004-05
Publisher
KLUWER ACADEMIC PUBL
Citation
BIOTECHNOLOGY LETTERS, Vol.26 No.9, pp.709-712
Abstract
Cell culture with serum-containing medium has potential problems associated with contamination of infectious agents. This study demonstrates for the first time the feasibility of regenerating cartilage tissues in vivo by implantation of chondrocytes cultured in vitro in a chemically-defined, serum-free medium. Chondrocytes cultured in the serum-free medium grew similarly to those in a serum-containing medium. Implantation of chondrocytes cultured in the serum-free medium and seeded on to polymer scaffolds resulted in the regeneration of cartilage tissues with histological aspects similar to those of cartilage tissues regenerated from chondrocytes cultured in serum-containing medium.
ISSN
0141-5492
URI
https://hdl.handle.net/10371/204447
DOI
https://doi.org/10.1023/B:BILE.0000024093.94151.d8
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  • College of Engineering
  • School of Chemical and Biological Engineering
Research Area biomaterials, nanomedicine, regenerative medicine

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