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Stable hepatocyte transplantation using fibrin matrix

Cited 16 time in Web of Science Cited 18 time in Scopus
Authors

So-Jung Gwak; Dongho Choi; Seung Sam Paik; Eun Yeol Lee; Kwang Soo Lee; Byung-Soo Kim

Issue Date
2004-03
Publisher
KLUWER ACADEMIC PUBL
Citation
BIOTECHNOLOGY LETTERS, Vol.26 No.6, pp.505-508
Abstract
Fibrin matrix, a naturally derived biodegradable polymer matrix, was evaluated as a scaffold for hepatocyte transplantation in an athymic mouse model. One week after transplantation, opaque conglomerates of the transplanted hepatocytes and fibrin matrix were found on the intestinal mesentery, whereas no transplanted hepatocytes were observed in control groups ( transplantation of hepatocytes suspended in culture medium). The hepatocytes in the conglomerates retained hepatocyte-specific functions, as examined with histochemical and immunohistochemical stainings. Stable hepatocyte engraftment may thus be achieved by hepatocyte transplantation using fibrin matrix.
ISSN
0141-5492
URI
https://hdl.handle.net/10371/204448
DOI
https://doi.org/10.1023/B:BILE.0000019558.99209.84
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  • College of Engineering
  • School of Chemical and Biological Engineering
Research Area biomaterials, nanomedicine, regenerative medicine

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