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Peripheral nerve regeneration using acellular nerve grafts

Cited 89 time in Web of Science Cited 107 time in Scopus
Authors

Byung‐Soo Kim; James J. Yoo; Anthony Atala

Issue Date
2004-02
Publisher
WILEY-LISS
Citation
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, Vol.68A No.2, pp.201-209
Abstract
Long gap peripheral nerve injuries usually require a graft to facilitate axonal regeneration into the distal nerve stump. The use of autografts is often limited because of graft availability and donor-site morbidity. We investigated whether acellular nerve allografts would provide an appropriate channel for the promotion and induction of sciatic nerve regeneration in rats. Axons sprouted from the proximal portion and reached the distal portion in the 1 cm-long grafts by 1 month. The number of axons in the regenerated nerves was similar to that of normal nerves at 1 month. Loading the grafts with betaNGF and VEGF increased the number and mean diameter of axons and neovascularization in the regenerated nerves at I month. The motor conduction velocity increased over time and reached 63 +/- 10% of that of normal nerves at 6 months. The nerve injuries treated with the acellular grafts had a significant improvement in motor, nociception, and proprioception function compared to untreated nerves. The results from this study suggest that acellular nerve allografts may be a useful biomaterial for functional peripheral nerve regeneration. (C) 2003 Wiley Periodicals, Inc.
ISSN
0021-9304
URI
https://hdl.handle.net/10371/204449
DOI
https://doi.org/10.1002/jbm.a.10045
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  • College of Engineering
  • School of Chemical and Biological Engineering
Research Area biomaterials, nanomedicine, regenerative medicine

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