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Suspension culture of anchorage-dependent animal cells using nanospheres of the biodegradable polymer, poly(lactic-co-glycolic acid)
Cited 16 time in
Web of Science
Cited 16 time in Scopus
- Authors
- Issue Date
- 2003-08
- Publisher
- KLUWER ACADEMIC PUBL
- Citation
- BIOTECHNOLOGY LETTERS, Vol.25 No.16, pp.1363-1367
- Abstract
- A novel method was developed for suspension culture of anchorage-dependent animal cells using biodegradable polymer nanospheres. The addition of poly(lactic-co-glycolic acid) nanospheres (907 nm average diam.) to the culture of human embryonic kidney 293 cells in stirred suspension bioreactors promoted the aggregate formation and cell growth (4.4-fold versus 2.2-fold growth for 7 d), compared to culture without nanospheres. This method may be useful for the culture of various types of anchorage-dependent animal cells in large-scale suspension bioreactors.
- ISSN
- 0141-5492
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