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Suspension culture of hematopoietic stem cells in stirred bioreactors
Cited 12 time in
Web of Science
Cited 13 time in Scopus
- Authors
- Issue Date
- 2003-01
- Publisher
- KLUWER ACADEMIC PUBL
- Citation
- BIOTECHNOLOGY LETTERS, Vol.25 No.2, pp.179-182
- Abstract
- Hematopoietic stem cells have applications in bone marrow transplantations for the treatment of hematopoietic disorders. When murine hematopoietic stem cells were cultured in 50 ml stirred bioreactors for 14 d, stem-cell-antigen-1 positive cells (hematopoietic primitive progenitor cells) and long-term culture-initiating cells (hematopoietic stem cells) grew by 5-fold and 4-fold, respectively. These results show the possibility of growing hematopoietic stem cells using a stirred bioreactor.
- ISSN
- 0141-5492
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