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Biomaterials for tissue engineering

Cited 226 time in Web of Science Cited 294 time in Scopus
Authors

Byung-Soo Kim; Carlos E. Baez; Anthony Atala

Issue Date
2000-02
Publisher
SPRINGER VERLAG
Citation
WORLD JOURNAL OF UROLOGY, Vol.18 No.1, pp.2-9
Abstract
Biomaterials play a critical role in the engineering of new functional genitourinary tissues for the replacement of lost or malfunctioning tissues. They provide a temporary scaffolding to guide new tissue growth and organization and may provide bioactive signals (e.g., cell-adhesion peptides and growth factors) required for the retention of tissue-specific gene expression. A variety of biomaterials, which can be classified into three types - naturally derived materials (e.g., collagen and alginate), acellular tissue matrices (e.g., bladder submucosa and small-intestinal submucosa), and synthetic polymers [e.g., polyglycolic acid, polylactic acid, and poly(lactic-co-glycolic acid)] - have proved to be useful in the reconstruction of a number of genitourinary tissues in animal models. Some of these materials are currently being used clinically for genitourinary applications. Ultimately the development or selection of appropriate biomaterials may allow the engineering of multiple types of functional genitourinary tissues.
ISSN
0724-4983
URI
https://hdl.handle.net/10371/204469
DOI
https://doi.org/10.1007/s003450050002
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  • College of Engineering
  • School of Chemical and Biological Engineering
Research Area biomaterials, nanomedicine, regenerative medicine

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