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Cyclic mechanical strain regulates the development of engineered smooth muscle tissue

Cited 363 time in Web of Science Cited 408 time in Scopus
Authors

Byung-Soo Kim; Janeta Nikolovski; Jeffrey Bonadio; David J. Mooney

Issue Date
1999-10
Publisher
NATURE AMERICA INC
Citation
NATURE BIOTECHNOLOGY, Vol.17 No.10, pp.979-983
Abstract
We show that the appropriate combinations of mechanical stimuli and polymeric scaffolds can enhance the mechanical properties of engineered tissues. The mechanical properties of tissues engineered from cells and polymer scaffolds are significantly lower than the native tissues they replace. We hypothesized that application of mechanical stimuli to engineered tissues would alter their mechanical properties. Smooth muscle tissue was engineered on two different polymeric scaffolds and subjected to cyclic mechanical strain. Short-term application of strain increased proliferation of smooth muscle cells (SMCs) and expression of collagen and elastin, but only when SMCs were adherent to specific scaffolds. Long-term application of cyclic strain upregulated elastin and collagen gene expression and led to increased organization in tissues. This resulted in more than an order of magnitude increase in the mechanical properties of the tissues.
ISSN
1087-0156
URI
https://hdl.handle.net/10371/204472
DOI
https://doi.org/10.1038/13671
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  • College of Engineering
  • School of Chemical and Biological Engineering
Research Area biomaterials, nanomedicine, regenerative medicine

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