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Production of human hematopoietic progenitors in a clinical-scale stirred suspension bioreactor
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, BS | - |
dc.date.accessioned | 2024-06-13T02:25:39Z | - |
dc.date.available | 2024-06-13T02:25:39Z | - |
dc.date.created | 2018-06-18 | - |
dc.date.issued | 1998-06 | - |
dc.identifier.citation | BIOTECHNOLOGY LETTERS, Vol.20 No.6, pp.595-601 | - |
dc.identifier.issn | 0141-5492 | - |
dc.identifier.uri | https://hdl.handle.net/10371/204483 | - |
dc.description.abstract | Ex vivo expanded primitive hematopoietic cells can be utilized in bone marrow transplantation therapies to treat patients suffering from various cancers and hematopoietic malignancies. A high initial cell density (10(6) cells/mL) and the supplement of soluble factors secreted by stromal feeders in combination with growth-promoting (interleukin-3 and stem cell factor) and growth-inhibiting (macrophage-inflammatory protein-1 alpha) cytokines resulted in high, long-term expansions (17-fold over a 14-day culture period) of human hematopoietic progenitors in a stirred suspension bioreactor. This study demonstrated that a transplantable dosage of human hematopoietic progenitor cells (8.1 +/- 1.3 x 10(6) colony forming unit-granulocyte/macrophage) can be generated from approximately 10 mL of bone marrow aspirate in a 14-day culture using a 250 mL suspension bioreactor system. | - |
dc.language | 영어 | - |
dc.publisher | KLUWER ACADEMIC PUBL | - |
dc.title | Production of human hematopoietic progenitors in a clinical-scale stirred suspension bioreactor | - |
dc.type | Article | - |
dc.identifier.doi | 10.1023/A:1005362030908 | - |
dc.citation.journaltitle | BIOTECHNOLOGY LETTERS | - |
dc.identifier.wosid | 000074968500015 | - |
dc.identifier.scopusid | 2-s2.0-0031872673 | - |
dc.citation.endpage | 601 | - |
dc.citation.number | 6 | - |
dc.citation.startpage | 595 | - |
dc.citation.volume | 20 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Kim, BS | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | HUMAN BONE-MARROW | - |
dc.subject.keywordPlus | STEM-CELL FACTOR | - |
dc.subject.keywordPlus | EX-VIVO | - |
dc.subject.keywordPlus | CULTURES | - |
dc.subject.keywordPlus | TRANSPLANTATION | - |
dc.subject.keywordPlus | EXPANSION | - |
dc.subject.keywordPlus | INTERLEUKIN-3 | - |
dc.subject.keywordPlus | INVITRO | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
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