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Development of technologies aiding large-tissue engineering

Cited 94 time in Web of Science Cited 105 time in Scopus
Authors

Eiselt, P; Kim, BS; Chacko, B; Isenberg, B; Peters, MC; Greene, KG; Roland, WD; Loebsack, AB; Burg, KJL; Culberson, C; Halberstadt, CR; Holder, WD; Mooney, DJ

Issue Date
1998-01
Publisher
AMER CHEMICAL SOC
Citation
BIOTECHNOLOGY PROGRESS, Vol.14 No.1, pp.134-140
Abstract
There are many clinical situations in which a large tissue mass is required to replace tissue lost to surgical resection (e.g. mastectomy). It is possible that autologous cell transplantation on biodegradable polymer matrices may provide a new therapy to engineer large tissue which can be used to treat these patients. A number of challenges must be met to engineer a large soft tissue mass. These include the design of (1) a structural framework to maintain a space for tissue development, (2) a space-filling matrix which provides for localization of transplanted cells, and (3) a stragegyto enhance vascularization of the forming tissue. in this paper we provide an overview of several technologies which are under development to address these issues. Specifically, support matrices to maintain a space for tissue development have been fabricated from polymers of lactide and glycolide. The ability of these structures to resist compressive forces was regulated by a ratio lactide to glycolide in the polymer. Smooth muscle cell seeding onto polyglycolide fiber-based matrices has been optimized to allow formation of new tissues in vitro and in vivo. Finally, polymer microsphere drug delivery technology is being developed to release vascular endothelial growth factor (VEGF), a potent angiogenic molecule, at the site of tissue formation. This strategy, which combines several different technologies, may ultimately allow for engineering of large soft tissues.
ISSN
8756-7938
URI
https://hdl.handle.net/10371/204486
DOI
https://doi.org/10.1021/bp970135h
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  • College of Engineering
  • School of Chemical and Biological Engineering
Research Area biomaterials, nanomedicine, regenerative medicine

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