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Novel analysis model for implant osseointegration using ectopic bone formation via the recombinant human bone morphogenetic protein-2/macroporous biphasic calcium phosphate block system in rats: a proof-of-concept study
DC Field | Value | Language |
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dc.contributor.author | Park, Jung-Chul | - |
dc.contributor.author | Lee, Jong-Bin | - |
dc.contributor.author | Daculsi, Guy | - |
dc.contributor.author | Oh, Sang-Yeop | - |
dc.contributor.author | Cho, Kyoo-Sung | - |
dc.contributor.author | Im, Gun-Il | - |
dc.contributor.author | Kim, Byung-Soo | - |
dc.contributor.author | Kim, Chang-Sung | - |
dc.date.accessioned | 2024-06-14T01:02:32Z | - |
dc.date.available | 2024-06-14T01:02:32Z | - |
dc.date.created | 2018-06-19 | - |
dc.date.created | 2018-06-19 | - |
dc.date.issued | 2012-08 | - |
dc.identifier.citation | JOURNAL OF PERIODONTAL AND IMPLANT SCIENCE, Vol.42 No.4, pp.136-143 | - |
dc.identifier.issn | 2093-2278 | - |
dc.identifier.uri | https://hdl.handle.net/10371/204516 | - |
dc.description.abstract | Purpose: The osseointegration around titanium mini-implants installed in macroporous biphasic calcium phosphate (MBCP) blocks was evaluated after incubation with recombinant human bone morphogenetic protein-2 (rhBMP-2) in an ectopic subcutaneous rat model. Methods: Mini-implants (phi 1.8x12 mm) were installed in MBCP blocks (bMBCPs, 4x5x15 mm) loaded with rhBMP-2 at 0.1 mg/mL, and then implanted for 8 weeks into subcutaneous pockets of male Sprague-Dawley rats (n = 10). A histomorphometric analysis was performed, and the bone-to-implant contact (BIC) and bone density were evaluated. Results: Significant osteoinductive activity was induced in the rhBMP-2/bMBCP group. The percentage of BIC was 41.23 +/- 4.13% (mean +/- standard deviation), while bone density was 33.47 +/- 5.73%. In contrast, no bone formation was observed in the bMBCP only group. Conclusions: This model represents a more standardized tool for analyzing osseointegration and bone healing along the implant surface and in bMBCPs that excludes various healing factors derived from selected animals and defect models. | - |
dc.language | 영어 | - |
dc.publisher | KOREAN ACAD PERIODONTOLOGY | - |
dc.title | Novel analysis model for implant osseointegration using ectopic bone formation via the recombinant human bone morphogenetic protein-2/macroporous biphasic calcium phosphate block system in rats: a proof-of-concept study | - |
dc.type | Article | - |
dc.identifier.doi | 10.5051/jpis.2012.42.4.136 | - |
dc.citation.journaltitle | JOURNAL OF PERIODONTAL AND IMPLANT SCIENCE | - |
dc.identifier.wosid | 000209077000005 | - |
dc.identifier.scopusid | 2-s2.0-84867630326 | - |
dc.citation.endpage | 143 | - |
dc.citation.number | 4 | - |
dc.citation.startpage | 136 | - |
dc.citation.volume | 42 | - |
dc.identifier.kciid | ART001692900 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Kim, Byung-Soo | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordAuthor | Animals | - |
dc.subject.keywordAuthor | Dental implants | - |
dc.subject.keywordAuthor | Osseointegration | - |
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