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Efficient Bone Regeneration Induced by Bone Morphogenetic Protein-2 Released from Apatite-Coated Collagen Scaffolds
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yang, Hee Seok | - |
dc.contributor.author | La, Wan-Geun | - |
dc.contributor.author | Park, Jooyeon | - |
dc.contributor.author | Kim, Chang-Sung | - |
dc.contributor.author | Im, Gun-Il | - |
dc.contributor.author | Kim, Byung-Soo | - |
dc.date.accessioned | 2024-06-14T01:02:53Z | - |
dc.date.available | 2024-06-14T01:02:53Z | - |
dc.date.created | 2018-06-19 | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION, Vol.23 No.13, pp.1659-1671 | - |
dc.identifier.issn | 0920-5063 | - |
dc.identifier.uri | https://hdl.handle.net/10371/204523 | - |
dc.description.abstract | Bone morphogenetic proteins (BMPs) are the most potent osteoinductive growth factors. Clinically utilized BMP-2 uses a type-I collagen scaffold as a carrier. Here we hypothesized that an apatite coating on a type-I collagen scaffold would prolong the BMP-2 release period and enhance bone regeneration in calvarial defects in mice. Apatite coating was achieved by incubating collagen scaffolds in simulated body fluid. BMP-2 release kinetics and bioactivity were evaluated by enzyme-linked immunosorbent assay and alkaline phosphatase activity measurement of cultured osteoblasts. Computed tomography and histomorphometry were performed eight weeks after various doses of BMP-2 were delivered to mouse calvarial defects using either non-modified or apatite-coated collagen scaffolds. Apatite-coated collagen scaffolds released 91.8 +/- 11.5% of the loaded BMP-2 over 13 days in vitro, whereas non-modified collagen scaffolds released 98.3 +/- 2.2% over the initial one day. The in vivo study showed that BMP-2 delivery with apatite-coated collagen scaffolds resulted in a significantly greater bone formation area and higher bone density than that with non-modified collagen scaffolds. This study suggests that simple apatite coating on collagen scaffolds can enhance the bone regeneration efficacy of BMP-2 released from collagen scaffolds. (C) Koninklijke Brill NV, Leiden, 2011 | - |
dc.language | 영어 | - |
dc.publisher | TAYLOR & FRANCIS LTD | - |
dc.title | Efficient Bone Regeneration Induced by Bone Morphogenetic Protein-2 Released from Apatite-Coated Collagen Scaffolds | - |
dc.type | Article | - |
dc.identifier.doi | 10.1163/092050611X589419 | - |
dc.citation.journaltitle | JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION | - |
dc.identifier.wosid | 000308105900002 | - |
dc.identifier.scopusid | 2-s2.0-84867192410 | - |
dc.citation.endpage | 1671 | - |
dc.citation.number | 13 | - |
dc.citation.startpage | 1659 | - |
dc.citation.volume | 23 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Kim, Byung-Soo | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordPlus | EFFICACY | - |
dc.subject.keywordPlus | ENHANCEMENT | - |
dc.subject.keywordPlus | CARRIERS | - |
dc.subject.keywordPlus | REPAIR | - |
dc.subject.keywordPlus | BMP-2 | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordAuthor | Apatite coating | - |
dc.subject.keywordAuthor | bone morphogenetic protein-2 | - |
dc.subject.keywordAuthor | bone regeneration | - |
dc.subject.keywordAuthor | collagen scaffold | - |
dc.subject.keywordAuthor | osteoconductivity | - |
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