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Orthotopic bone formation by implantation of apatite-coated poly(lactide-co-glycolide)/hydroxyapatite composite particulates and bone morphogenetic protein-2
DC Field | Value | Language |
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dc.contributor.author | Kim, Sang-Soo | - |
dc.contributor.author | Gwak, So-Jung | - |
dc.contributor.author | Kim, Byung-Soo | - |
dc.date.accessioned | 2024-06-14T01:03:34Z | - |
dc.date.available | 2024-06-14T01:03:34Z | - |
dc.date.created | 2018-06-18 | - |
dc.date.issued | 2008-10 | - |
dc.identifier.citation | JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, Vol.87A No.1, pp.245-253 | - |
dc.identifier.issn | 1549-3296 | - |
dc.identifier.uri | https://hdl.handle.net/10371/204536 | - |
dc.description.abstract | Bone morphogenetic proteins (BMPs) are the most potent osteoinductive growth factors. However, a delivery system is essential to take advantage of the osteoinductive effect of BMPs. In the present study, we tested the suitability of apatite-coated poly(D,L-lactide-co-glycolide)/nanohydroxyapatite (PLGA/HA) particulates as carriers for the controlled release of BMP-2. The release of BMP-2 from apatite-coated PLGA/HA particulates was sustained for at least 4 weeks in vitro. A delivery system of apatite-coated PLGA/HA particulates suspended In fibrin gel further slowed the BMP-2 release rate. In vivo implantation of either Fibrin gel + BMP-2 or Fibrin gel + apatite-coated PLGA/HA particulates showed enhanced new bone formation in critical-sized calvarial defects of rats 8 weeks after implantation, compared to implantation of fibrin gel only. Importantly, new bone formation was Much higher in the defects treated with BMP-2 delivery using apatite-coated PLGA/HA particulates in fibrin gel (Fibrin gel + PLGA/HA + BMP-2 group) than in the defects treated either with apatite-coated PLGA/HA particulates in fibrin gel (Fibrin gel + BMP-2 group) or with BMP-2 delivery using fibrin gel alone (Fibrin gel + BMP-2 group). BMP-2 and osteoinductive HA had an additive effect on orthotopic bone formation. In conclusion, the apatite-coated PLGA/HA particulates showed good results as carriers for BMP-2. The BMP-2 delivery system showed high osteogenic capability in a rat calvarial bone defect model. The local and sustained delivery system for BMP-2 developed in this Study may be useful as a carrier for BMP-2 and would enhance bone regeneration efficacy for the treatment of large bone defects. (C) 2008 Wiley Periodicals, Inc. | - |
dc.language | 영어 | - |
dc.publisher | WILEY-BLACKWELL | - |
dc.title | Orthotopic bone formation by implantation of apatite-coated poly(lactide-co-glycolide)/hydroxyapatite composite particulates and bone morphogenetic protein-2 | - |
dc.type | Article | - |
dc.identifier.doi | 10.1002/jbm.a.31782 | - |
dc.citation.journaltitle | JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A | - |
dc.identifier.wosid | 000259129500029 | - |
dc.identifier.scopusid | 2-s2.0-51849089563 | - |
dc.citation.endpage | 253 | - |
dc.citation.number | 1 | - |
dc.citation.startpage | 245 | - |
dc.citation.volume | 87A | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Kim, Byung-Soo | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | SCAFFOLDS IN-VITRO | - |
dc.subject.keywordPlus | CONTROLLED-RELEASE | - |
dc.subject.keywordPlus | BIOMIMETIC PROCESS | - |
dc.subject.keywordPlus | HYDROXYAPATITE | - |
dc.subject.keywordPlus | POLYMERS | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordPlus | CARRIERS | - |
dc.subject.keywordAuthor | bone regeneration | - |
dc.subject.keywordAuthor | bone tissue engineering | - |
dc.subject.keywordAuthor | bone morphogenetic protein | - |
dc.subject.keywordAuthor | controlled release | - |
dc.subject.keywordAuthor | hydroxyapatite | - |
dc.subject.keywordAuthor | simulated body fluid | - |
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