Publications

Detailed Information

Control of the molecular degradation of hyaluronic acid hydrogels for tissue augmentation

Cited 89 time in Web of Science Cited 92 time in Scopus
Authors

Oh, Eun Ju; Kang, Sun-Woong; Kim, Byung-Soo; Jiang, Ge; Cho, Il Hwan; Hahn, Sei Kwang

Issue Date
2008-09
Publisher
WILEY-LISS
Citation
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, Vol.86A No.3, pp.685-693
Abstract
A novel protocol to control the molecular degradation of hyaluronic acid (HA) hydrogels was successfully developed for tissue augmentation applications. HA has a different conformational structure in water and organic solvent, and the carboxyl group of HA is known to be the recognition site of hyaluronidase and HA receptors. Based on these findings, HA was chemically modified by grafting adipic acid dihydrazide (ADH) to the carboxyl group of HA in the water to prepare HA-ADH(WATER) and in the mixed solvent of water and ethanol to prepare degradation-controlled HA-ADH(WATER/ETHANOL-) Three kinds of HA hydrogels were prepared by the crosslinking of HA-ADH(WATER) or HA-ADH(WATER/ETHANOL) with bis(sul-fosuccinimidyl) suberate, and by the crosslinking of HA-OH with divinyl sulfone (DVS). In vitro and in vivo degradation tests showed that HA-DVS hydrogels were degraded most rapidly, followed by HA-ADH(WATER) hydrogels and HA-ADH(WATER/ETHANOL) hydrogels. There was no adverse effect during and after in vivo degradation tests. All of the HA hydrogel samples appeared to be biocompatible, according to the histological analysis with hematoxylin-eosin and Alcian blue. (c) 2007 Wiley Periodicals, Inc.
ISSN
1549-3296
URI
https://hdl.handle.net/10371/204537
DOI
https://doi.org/10.1002/jbm.a.31681
Files in This Item:
There are no files associated with this item.
Appears in Collections:

Related Researcher

  • College of Engineering
  • School of Chemical and Biological Engineering
Research Area biomaterials, nanomedicine, regenerative medicine

Altmetrics

Item View & Download Count

  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Share