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Bone morphogenetic protein-2 enhances bone regeneration mediated by transplantation of osteogenically undifferentiated bone marrow-derived mesenchymal stem cells
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kang, Sun-Woong | - |
dc.contributor.author | La, Wan-Geun | - |
dc.contributor.author | Kang, Jin Muk | - |
dc.contributor.author | Park, Jung-Ho | - |
dc.contributor.author | Kim, Byung-Soo | - |
dc.date.accessioned | 2024-06-14T01:03:49Z | - |
dc.date.available | 2024-06-14T01:03:49Z | - |
dc.date.created | 2018-06-18 | - |
dc.date.issued | 2008-07 | - |
dc.identifier.citation | BIOTECHNOLOGY LETTERS, Vol.30 No.7, pp.1163-1168 | - |
dc.identifier.issn | 0141-5492 | - |
dc.identifier.uri | https://hdl.handle.net/10371/204541 | - |
dc.description.abstract | We have hypothesized that human bone marrow-derived mesenchymal stem cells (BMMSCs), that are not osteogenically differentiated prior to implantation, would regenerate bone extensively in vivo once exogenous bone morphogenetic protein-2 (BMP-2) was delivered to the implantation site. BMP-2 released from heparin-conjugated poly(lactic-co-glycolic acid) (HCPLGA) scaffolds stimulates osteogenic differentiation of cultured BMMSCs. Upon implantation, undifferentiated BMMSCs on BMP-2-loaded HCPLGA scaffolds induce far more extensive bone formation than either undifferentiated BMMSCs or osteogenically differentiated BMMSCs on HCPLGA scaffolds. These BMP-2-loaded HCPLGA scaffolds could prove invaluable for in vivo regeneration of bone from undifferentiated human BMMSCs. | - |
dc.language | 영어 | - |
dc.publisher | SPRINGER | - |
dc.title | Bone morphogenetic protein-2 enhances bone regeneration mediated by transplantation of osteogenically undifferentiated bone marrow-derived mesenchymal stem cells | - |
dc.type | Article | - |
dc.identifier.doi | 10.1007/s10529-008-9675-8 | - |
dc.citation.journaltitle | BIOTECHNOLOGY LETTERS | - |
dc.identifier.wosid | 000256475900004 | - |
dc.identifier.scopusid | 2-s2.0-44949119587 | - |
dc.citation.endpage | 1168 | - |
dc.citation.number | 7 | - |
dc.citation.startpage | 1163 | - |
dc.citation.volume | 30 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Kim, Byung-Soo | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | STROMAL CELLS | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | HYDROXYAPATITE | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | SCAFFOLD | - |
dc.subject.keywordAuthor | bone marrow-derived stem cell | - |
dc.subject.keywordAuthor | bone morphogenetic protein-2 | - |
dc.subject.keywordAuthor | bone regeneration | - |
dc.subject.keywordAuthor | tissue engineering | - |
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