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Bone morphogenetic protein-2 enhances bone regeneration mediated by transplantation of osteogenically undifferentiated bone marrow-derived mesenchymal stem cells

DC Field Value Language
dc.contributor.authorKang, Sun-Woong-
dc.contributor.authorLa, Wan-Geun-
dc.contributor.authorKang, Jin Muk-
dc.contributor.authorPark, Jung-Ho-
dc.contributor.authorKim, Byung-Soo-
dc.date.accessioned2024-06-14T01:03:49Z-
dc.date.available2024-06-14T01:03:49Z-
dc.date.created2018-06-18-
dc.date.issued2008-07-
dc.identifier.citationBIOTECHNOLOGY LETTERS, Vol.30 No.7, pp.1163-1168-
dc.identifier.issn0141-5492-
dc.identifier.urihttps://hdl.handle.net/10371/204541-
dc.description.abstractWe have hypothesized that human bone marrow-derived mesenchymal stem cells (BMMSCs), that are not osteogenically differentiated prior to implantation, would regenerate bone extensively in vivo once exogenous bone morphogenetic protein-2 (BMP-2) was delivered to the implantation site. BMP-2 released from heparin-conjugated poly(lactic-co-glycolic acid) (HCPLGA) scaffolds stimulates osteogenic differentiation of cultured BMMSCs. Upon implantation, undifferentiated BMMSCs on BMP-2-loaded HCPLGA scaffolds induce far more extensive bone formation than either undifferentiated BMMSCs or osteogenically differentiated BMMSCs on HCPLGA scaffolds. These BMP-2-loaded HCPLGA scaffolds could prove invaluable for in vivo regeneration of bone from undifferentiated human BMMSCs.-
dc.language영어-
dc.publisherSPRINGER-
dc.titleBone morphogenetic protein-2 enhances bone regeneration mediated by transplantation of osteogenically undifferentiated bone marrow-derived mesenchymal stem cells-
dc.typeArticle-
dc.identifier.doi10.1007/s10529-008-9675-8-
dc.citation.journaltitleBIOTECHNOLOGY LETTERS-
dc.identifier.wosid000256475900004-
dc.identifier.scopusid2-s2.0-44949119587-
dc.citation.endpage1168-
dc.citation.number7-
dc.citation.startpage1163-
dc.citation.volume30-
dc.description.isOpenAccessN-
dc.contributor.affiliatedAuthorKim, Byung-Soo-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.subject.keywordPlusSTROMAL CELLS-
dc.subject.keywordPlusIN-VITRO-
dc.subject.keywordPlusGENE-EXPRESSION-
dc.subject.keywordPlusDIFFERENTIATION-
dc.subject.keywordPlusHYDROXYAPATITE-
dc.subject.keywordPlusPROLIFERATION-
dc.subject.keywordPlusSCAFFOLD-
dc.subject.keywordAuthorbone marrow-derived stem cell-
dc.subject.keywordAuthorbone morphogenetic protein-2-
dc.subject.keywordAuthorbone regeneration-
dc.subject.keywordAuthortissue engineering-
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  • College of Engineering
  • School of Chemical and Biological Engineering
Research Area biomaterials, nanomedicine, regenerative medicine

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