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Poly(lactic-co-glycolic acid) nanosphere as a vehicle for gene delivery to human cord blood-derived mesenchymal stem cells: comparison with polyethylenimine
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Gwak, So-Jung | - |
dc.contributor.author | Kim, Byung Soo | - |
dc.date.accessioned | 2024-06-14T01:03:52Z | - |
dc.date.available | 2024-06-14T01:03:52Z | - |
dc.date.created | 2018-06-18 | - |
dc.date.issued | 2008-07 | - |
dc.identifier.citation | BIOTECHNOLOGY LETTERS, Vol.30 No.7, pp.1177-1182 | - |
dc.identifier.issn | 0141-5492 | - |
dc.identifier.uri | https://hdl.handle.net/10371/204542 | - |
dc.description.abstract | Polyethylenimine (PEI) is one of the most extensively studied non-viral vectors but its cytotoxicity limits its clinical value. PLGA nanospheres are biocompatible and can facilitate sustained release of plasmid DNA. This study compares the cytotoxicity and long-term transgene expression between PLGA nanosphere and PEI. PLGA nanospheres were significantly less cytotoxic than PEI at various concentrations. PLGA nanospheres induced significantly higher transgene expression in vitro for a longer duration (21 days) than PEI. We conclude that PLGA nanospheres have potential as gene delivery vehicles for use in gene therapy for diseases in which a long-term therapeutic gene expression regimen is necessary. | - |
dc.language | 영어 | - |
dc.publisher | SPRINGER | - |
dc.title | Poly(lactic-co-glycolic acid) nanosphere as a vehicle for gene delivery to human cord blood-derived mesenchymal stem cells: comparison with polyethylenimine | - |
dc.type | Article | - |
dc.identifier.doi | 10.1007/s10529-008-9676-7 | - |
dc.citation.journaltitle | BIOTECHNOLOGY LETTERS | - |
dc.identifier.wosid | 000256475900006 | - |
dc.identifier.scopusid | 2-s2.0-44949144097 | - |
dc.citation.endpage | 1182 | - |
dc.citation.number | 7 | - |
dc.citation.startpage | 1177 | - |
dc.citation.volume | 30 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Kim, Byung Soo | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | ENDOTHELIAL GROWTH-FACTOR | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | CONTROLLED-RELEASE | - |
dc.subject.keywordPlus | DNA | - |
dc.subject.keywordPlus | VECTOR | - |
dc.subject.keywordPlus | MUSCLE | - |
dc.subject.keywordPlus | VITRO | - |
dc.subject.keywordAuthor | gene delivery | - |
dc.subject.keywordAuthor | non-viral vector | - |
dc.subject.keywordAuthor | polyethylenimine | - |
dc.subject.keywordAuthor | poly(lactic-co-glycolic acid) nanosphere | - |
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