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Metabolomic Characteristics of Nontuberculous Mycobacterial Pulmonary Disease
DC Field | Value | Language |
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dc.contributor.author | Kim, Jungeun | - |
dc.contributor.author | Chae, Woori | - |
dc.contributor.author | Kim, Joong-Yub | - |
dc.contributor.author | Yim, Jae-Joon | - |
dc.contributor.author | Cho, Joo-Youn | - |
dc.contributor.author | Kwak, Nakwon | - |
dc.date.accessioned | 2024-08-08T01:17:30Z | - |
dc.date.available | 2024-08-08T01:17:30Z | - |
dc.date.created | 2024-08-05 | - |
dc.date.created | 2024-08-05 | - |
dc.date.issued | 2024-02 | - |
dc.identifier.citation | JOURNAL OF INFECTIOUS DISEASES | - |
dc.identifier.issn | 0022-1899 | - |
dc.identifier.uri | https://hdl.handle.net/10371/204954 | - |
dc.description.abstract | Background The therapeutic challenges posed by nontuberculous mycobacterial pulmonary disease (NTM-PD) contribute to an unmet medical need. In this study, we aimed to investigate NTM-PD-specific metabolic pathways using serum metabolomics to understand disease pathogenesis.Methods Mass spectrometry-based untargeted metabolomic profiling of serum from patients with NTM-PD (n = 50), patients with bronchiectasis (n = 50), and healthy controls (n = 60) was performed. Selected metabolites were validated by an independent cohort and subjected to pathway analysis and classification modeling.Results Leucine, tyrosine, inosine, proline, 5-oxoproline, and hypoxanthine levels increased in the NTM-PD group compared with the healthy control group. Furthermore, levels of antioxidant metabolites (ferulic acid, alpha-lipoic acid, biotin, and 2,8-phenazinediamine) decreased in patients with NTM-PD. These changes were associated with arginine- and proline-related metabolism, leading to generation of reactive oxygen species. Interestingly, the observed metabolic changes in the NTM-PD group overlapped with those in the bronchiectasis group.Conclusions In NTM-PD, 11 metabolites linked to increased oxidative stress were significantly altered from those in healthy controls. Our findings enhance a comprehensive understanding of NTM-PD pathogenesis and provide insights for novel treatment approaches. Through use of an untargeted metabolomics approach, 11 metabolites were detected in the serum of NTM-PD patients. Metabolic alterations linked to arginine- and proline-related pathways were detected, suggesting an association with reactive oxygen species generation. | - |
dc.language | 영어 | - |
dc.publisher | OXFORD UNIV PRESS INC | - |
dc.title | Metabolomic Characteristics of Nontuberculous Mycobacterial Pulmonary Disease | - |
dc.type | Article | - |
dc.identifier.doi | 10.1093/infdis/jiae100 | - |
dc.citation.journaltitle | JOURNAL OF INFECTIOUS DISEASES | - |
dc.identifier.wosid | 001191836700001 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Yim, Jae-Joon | - |
dc.contributor.affiliatedAuthor | Cho, Joo-Youn | - |
dc.type.docType | Article; Early Access | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | NITRIC-OXIDE | - |
dc.subject.keywordPlus | HOST | - |
dc.subject.keywordPlus | TUBERCULOSIS | - |
dc.subject.keywordPlus | GLUTATHIONE | - |
dc.subject.keywordPlus | PROLINE | - |
dc.subject.keywordAuthor | untargeted metabolomics | - |
dc.subject.keywordAuthor | nontuberculous mycobacterial | - |
dc.subject.keywordAuthor | pulmonary disease | - |
dc.subject.keywordAuthor | bronchiectasis | - |
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