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Admission LDL-cholesterol, statin pretreatment and early outcomes in acute ischemic stroke
DC Field | Value | Language |
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dc.contributor.author | Kim, Joon-Tae | - |
dc.contributor.author | Lee, Ji Sung | - |
dc.contributor.author | Kim, Beom Joon | - |
dc.contributor.author | Kang, Jihoon | - |
dc.contributor.author | Lee, Keon-Joo | - |
dc.contributor.author | Park, Jong-Moo | - |
dc.contributor.author | Kang, Kyusik | - |
dc.contributor.author | Lee, Soo Joo | - |
dc.contributor.author | Kim, Jae Guk | - |
dc.contributor.author | Cha, Jae-Kwan | - |
dc.contributor.author | Kim, Dae-Hyun | - |
dc.contributor.author | Park, Tai Hwan | - |
dc.contributor.author | Lee, Kyungbok | - |
dc.contributor.author | Lee, Jun | - |
dc.contributor.author | Hong, Keun-Sik | - |
dc.contributor.author | Cho, Yong-Jin | - |
dc.contributor.author | Park, Hong-Kyun | - |
dc.contributor.author | Lee, Byung-Chul | - |
dc.contributor.author | Yu, Kyung-Ho | - |
dc.contributor.author | Oh, Mi Sun | - |
dc.contributor.author | Kim, Dong-Eog | - |
dc.contributor.author | Ryu, Wi-Sun | - |
dc.contributor.author | Choi, Jay Chol | - |
dc.contributor.author | Kwon, Jee-Hyun | - |
dc.contributor.author | Kim, Wook-Joo | - |
dc.contributor.author | Shin, Dong-Ick | - |
dc.contributor.author | Yum, Kyu Sun | - |
dc.contributor.author | Sohn, Sung Il | - |
dc.contributor.author | Hong, Jeong-Ho | - |
dc.contributor.author | Lee, Sang-Hwa | - |
dc.contributor.author | Park, Man-Seok | - |
dc.contributor.author | Choi, Kang-Ho | - |
dc.contributor.author | Lee, Juneyoung | - |
dc.contributor.author | Park, Kwang-Yeol | - |
dc.contributor.author | Bae, Hee-Joon | - |
dc.date.accessioned | 2024-08-08T01:20:21Z | - |
dc.date.available | 2024-08-08T01:20:21Z | - |
dc.date.created | 2024-01-17 | - |
dc.date.created | 2024-01-17 | - |
dc.date.issued | 2023-09 | - |
dc.identifier.citation | Journal of Clinical Lipidology, Vol.17 No.5, pp.612-621 | - |
dc.identifier.issn | 1933-2874 | - |
dc.identifier.uri | https://hdl.handle.net/10371/205194 | - |
dc.description.abstract | Background: Lipid paradox of low LDL-C may cause physicians to be reluctant to use statins in acute ischemic stroke (AIS) patients with low LDL-C levels at admission. Objective: This study investigated the association between LDL-C levels and early vascular outcomes and assessed the potential interaction effect between LDL-C and statin pretreatment on early outcomes.Patients and methods: This was a study of a prospective, multicenter, registry of AIS patients with admission LDL-C. The subjects were divided into 3 groups according to LDL-C levels: low LDL-C (<= 100 mg/dL); intermediate LDL-C ( > 100, < 130 mg/dL); and high LDL-C (>= 130 mg/dL). The primary early vascular outcome was a composite of stroke (ischemic or hemorrhagic), myocardial infarction and all-cause mortality within 3 months. The associations of LDL-C levels as a continuous variable and the risks of primary outcome using Cox proportional hazards models with restricted cubic splines were explored.Results: A total of 32,505 patients (age, 69 +/- 12; male, 58.6%) were analyzed. The 3 groups showed significant differences in the 3-month primary outcome, with highest events in the low LDLC group; after adjustment, no significant associations with the 3-month primary outcome remained. U-shaped nonlinear relationships of LDL-C levels with the 3-month primary outcome were observed (Pnon-linearity < 0.001), with substantial relationships in the no pretreatment subgroup.Conclusions: The relationships between admission LDL-C levels and early outcomes are complex but appear to be paradoxical in patients with low LDL-C and no statin pretreatment. The results suggest that statin pretreatment might offset the paradoxical response of low LDL-C on early vascular outcomes. Further study would be warranted.(c) 2023 National Lipid Association. Published by Elsevier Inc. All rights reserved. | - |
dc.language | 영어 | - |
dc.publisher | Elsevier BV | - |
dc.title | Admission LDL-cholesterol, statin pretreatment and early outcomes in acute ischemic stroke | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.jacl.2023.08.002 | - |
dc.citation.journaltitle | Journal of Clinical Lipidology | - |
dc.identifier.wosid | 001134013700001 | - |
dc.identifier.scopusid | 2-s2.0-85171421728 | - |
dc.citation.endpage | 621 | - |
dc.citation.number | 5 | - |
dc.citation.startpage | 612 | - |
dc.citation.volume | 17 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Kim, Beom Joon | - |
dc.contributor.affiliatedAuthor | Bae, Hee-Joon | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | DENSITY-LIPOPROTEIN CHOLESTEROL | - |
dc.subject.keywordPlus | ACUTE MYOCARDIAL-INFARCTION | - |
dc.subject.keywordPlus | MORTALITY | - |
dc.subject.keywordPlus | LEVEL | - |
dc.subject.keywordPlus | CERIVASTATIN | - |
dc.subject.keywordPlus | MULTICENTER | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | SUBTYPE | - |
dc.subject.keywordAuthor | Lipid paradox | - |
dc.subject.keywordAuthor | LDL-cholesterol | - |
dc.subject.keywordAuthor | Acute ischemic stroke | - |
dc.subject.keywordAuthor | Early vascular outcome | - |
dc.subject.keywordAuthor | Statin pretreatment | - |
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