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Statin Treatment in Patients With Stroke With Low-Density Lipoprotein Cholesterol Levels Below 70 mg/dL
DC Field | Value | Language |
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dc.contributor.author | Kim, Joon-Tae | - |
dc.contributor.author | Lee, Ji Sung | - |
dc.contributor.author | Kim, Beom Joon | - |
dc.contributor.author | Kang, Jihoon | - |
dc.contributor.author | Lee, Keon-Joo | - |
dc.contributor.author | Park, Jong-Moo | - |
dc.contributor.author | Kang, Kyusik | - |
dc.contributor.author | Lee, Soo Joo | - |
dc.contributor.author | Kim, Jae Guk | - |
dc.contributor.author | Cha, Jae-Kwan | - |
dc.contributor.author | Kim, Dae-Hyun | - |
dc.contributor.author | Park, Tai Hwan | - |
dc.contributor.author | Lee, Kyungbok | - |
dc.contributor.author | Lee, Jun | - |
dc.contributor.author | Hong, Keun-Sik | - |
dc.contributor.author | Cho, Yong-Jin | - |
dc.contributor.author | Park, Hong-Kyun | - |
dc.contributor.author | Lee, Byung-Chul | - |
dc.contributor.author | Yu, Kyung-Ho | - |
dc.contributor.author | Oh, Mi Sun | - |
dc.contributor.author | Kim, Dong-Eog | - |
dc.contributor.author | Ryu, Wi-Sun | - |
dc.contributor.author | Choi, Jay Chol | - |
dc.contributor.author | Kwon, Jee-Hyun | - |
dc.contributor.author | Kim, Wook-Joo | - |
dc.contributor.author | Shin, Dong-Ick | - |
dc.contributor.author | Yum, Kyu Sun | - |
dc.contributor.author | Sohn, Sung Il | - |
dc.contributor.author | Hong, Jeong-Ho | - |
dc.contributor.author | Lee, Sang-Hwa | - |
dc.contributor.author | Park, Man-Seok | - |
dc.contributor.author | Choi, Kang-Ho | - |
dc.contributor.author | Lee, Juneyoung | - |
dc.contributor.author | Park, Kwang-Yeol | - |
dc.contributor.author | Bae, Hee-Joon | - |
dc.date.accessioned | 2024-08-08T01:20:21Z | - |
dc.date.available | 2024-08-08T01:20:21Z | - |
dc.date.created | 2023-12-15 | - |
dc.date.created | 2023-12-15 | - |
dc.date.issued | 2023-09 | - |
dc.identifier.citation | Journal of the American Heart Association, Vol.12 No.18, p. e030738 | - |
dc.identifier.issn | 2047-9980 | - |
dc.identifier.uri | https://hdl.handle.net/10371/205195 | - |
dc.description.abstract | Background: It is unclear whether statin treatment could reduce the risk of early vascular events when baseline low-density lipoprotein cholesterol (LDL-C) levels are already low, at <70mg/dL, at the time of the index stroke. Methods and Results: This study was an analysis of a prospective, multicenter, nationwide registry of consecutive patients with first-ever acute ischemic stroke with baseline low-density lipoprotein cholesterol levels <70mg/dL and without statin pretreatment. An inverse probabilities of treatment weights method was applied to control for imbalances in baseline characteristics. The primary outcome was a composite of stroke (either hemorrhagic or ischemic), myocardial infarction, and all-cause death within 3months. A total of 2850 patients (age, 69.513.4 years; men, 63.5%) were analyzed for this study. In-hospital statin treatment was used for 74.2% of patients. The primary composite outcome within 3months occurred in 21.5% of patients in the nonstatin group and 6.7% of patients in the statin group (P<0.001), but the rates of stroke (2.65% versus 2.33%), hemorrhagic stroke (0.16% versus 0.10%), and myocardial infarction (0.73% versus 0.19%) were not significantly different between the 2 groups. After inverse probability of treatment weighting analysis, the primary composite outcome was significantly reduced in patients with statin therapy (weighted hazard ratio [HR], 0.54 [95% CI, 0.42-0.69]). However, statin treatment did not increase the risk of hemorrhagic stroke (weighted HR, 1.11 [95% CI, 0.10-12.28]). Conclusions: Approximately three-quarters of the patients with first-ever ischemic stroke with baseline low-density lipoprotein cholesterol levels <70mg/dL received in-hospital statin treatment. Statin treatment, compared with no statin treatment, was significantly associated with a reduced risk of the 3-month primary composite outcomes and all-cause death but did not alter the rate of stroke recurrence. | - |
dc.language | 영어 | - |
dc.publisher | Wiley-Blackwell | - |
dc.title | Statin Treatment in Patients With Stroke With Low-Density Lipoprotein Cholesterol Levels Below 70 mg/dL | - |
dc.type | Article | - |
dc.identifier.doi | 10.1161/JAHA.123.030738 | - |
dc.citation.journaltitle | Journal of the American Heart Association | - |
dc.identifier.wosid | 001111277700036 | - |
dc.identifier.scopusid | 2-s2.0-85171783374 | - |
dc.citation.number | 18 | - |
dc.citation.startpage | e030738 | - |
dc.citation.volume | 12 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Kim, Beom Joon | - |
dc.contributor.affiliatedAuthor | Bae, Hee-Joon | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | ACUTE ISCHEMIC-STROKE | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | PARTICIPANTS | - |
dc.subject.keywordPlus | CERIVASTATIN | - |
dc.subject.keywordPlus | METAANALYSIS | - |
dc.subject.keywordPlus | EFFICACY | - |
dc.subject.keywordPlus | BENEFIT | - |
dc.subject.keywordPlus | SAFETY | - |
dc.subject.keywordAuthor | acute ischemic stroke | - |
dc.subject.keywordAuthor | early vascular outcomes | - |
dc.subject.keywordAuthor | LDL-C | - |
dc.subject.keywordAuthor | statin | - |
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